Chikungunya Virus Perturbs the Wnt/β-catenin Signaling Pathway for Efficient Viral Infection

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2023 Oct 20

PMID 37861335

Authors

Sanchari Chatterjee

Soumyajit Ghosh

Ankita Datey

Chandan Mahish

Subhasis Chattopadhyay

Soma Chattopadhyay

Affiliations

Soon will be listed here.

Abstract

Being obligate parasites, viruses use various host cell machineries in effectively replicating their genome, along with virus-encoded enzymes. In order to carry out infection and pathogenesis, viruses are known to manipulate fundamental cellular processes in cells and interfere with host gene expression. Several viruses interact with the cellular proteins involved in the Wnt/β-catenin pathway; however, reports regarding the involvement of protein components of the Wnt/β-catenin pathway in Chikungunya virus (CHIKV) infection are scarce. Additionally, there are currently no remedies or vaccines available for CHIKV. This is the first study to report that modulation of the Wnt/β-catenin pathway is crucial for effective CHIKV infection. These investigations deepen the understanding of the underlying mechanisms of CHIKV infection and offer new avenue for developing effective countermeasures to efficiently manage CHIKV infection.

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