Non-digestible Oligosaccharides-based Prebiotics to Ameliorate Obesity: Overview of Experimental Evidence and Future Perspectives

Overview

Journal Food Sci Biotechnol

Specialty Biotechnology

Date 2023 Oct 20

PMID 37860742

Authors

G Divyashri

Pothiyappan Karthik

T P Krishna Murthy

Dey Priyadarshini

Kakarla Raghava Reddy

Anjanapura V Raghu

Vinoth Kumar Vaidyanathan

Affiliations

Soon will be listed here.

Abstract

The diverse populations reportedly suffer from obesity on a global scale, and inconclusive evidence has indicated that both environmental and genetic factors are associated with obesity development. Therefore, a need exists to examine potential therapeutic or prophylactic molecules for obesity treatment. Prebiotics with non-digestible oligosaccharides (NDOs) have the potential to treat obesity. A limited number of prebiotic NDOs have demonstrated their ability as a convincing therapeutic solution to encounter obesity through various mechanisms, viz stimulating beneficial microorganisms, reducing the population of pathogenic microorganisms, and also improving lipid metabolism and glucose homeostasis. NDOs include pectic-oligosaccharides, fructo-oligosaccharides, xylo-oligosaccharides, isomalto-oligosaccharides, manno-oligosaccharides and other oligosaccharides which significantly influence the overall human health by different mechanisms. This review provides the treatment of obesity benefits by incorporating these prebiotic NDOs, according to established scientific research, which shows their good effects extend beyond the colon.

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