Single-cell Transcriptomics Provide Insight into Metastasis-related Subsets of Breast Cancer

Overview

Journal Breast Cancer Res

Specialty Oncology

Date 2023 Oct 20

PMID 37858183

Authors

Shikun Zhu

Mi Zhang

Xuexue Liu

Qing Luo

Jiahong Zhou

Miao Song

Jia Feng

Jinbo Liu

Affiliations

Soon will be listed here.

Abstract

Breast cancer metastasis is a complex, multi-step process, with high cellular heterogeneity between primary and metastatic breast cancer, and more complex interactions between metastatic cancer cells and other cells in the tumor microenvironment. High-resolution single-cell transcriptome sequencing technology can visualize the heterogeneity of malignant and non-malignant cells in the tumor microenvironment in real time, especially combined with spatial transcriptome analysis, which can directly compare changes between different stages of metastatic samples. Therefore, this study takes single-cell analysis as the first perspective to deeply explore special or rare cell subpopulations related to breast cancer metastasis, systematically summarizes their functions, molecular features, and corresponding treatment strategies, which will contribute to accurately identify, understand, and target tumor metastasis-related driving events, provide a research basis for the mechanistic study of breast cancer metastasis, and provide new clues for its personalized precision treatment.

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