Repair of Osteochondral Defects: Efficacy of a Tissue-engineered Hybrid Implant Containing Both Human MSC and Human IPSC-cartilaginous Particles

Overview

Journal NPJ Regen Med

Date 2023 Oct 19

PMID 37857652

Authors

Shinichi Nakagawa

Wataru Ando

Kazunori Shimomura

David A Hart

Hiroto Hanai

George Jacob

Ryota Chijimatsu

Seido Yarimitu

Hiromichi Fujie

Seiji Okada

Noriyuki Tsumaki

Norimasa Nakamura

Affiliations

Soon will be listed here.

Abstract

Both mesenchymal stromal cells (MSC) and induced pluripotent stem cells (iPSC) offer the potential for repair of damaged connective tissues. The use of hybrid implants containing both human MSC and iPSC was investigated to assess their combined potential to yield enhanced repair of osteochondral defects. Human iPSC-CP wrapped with tissue engineered constructs (TEC) containing human MSC attained secure defect filling with good integration to adjacent tissue in a rat osteochondral injury model. The presence of living MSC in the hybrid implants was required for effective biphasic osteochondral repair. Thus, the TEC component of such hybrid implants serves several critical functions including, adhesion to the defect site via the matrix and facilitation of the repair via live MSC, as well as enhanced angiogenesis and neovascularization. Based on these encouraging studies, such hybrid implants may offer an effective future intervention for repair of complex osteochondral defects.

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