Liver Injury Monitoring Using Dynamic Fluorescence Molecular Tomography Based on a Time-energy Difference Strategy

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2023 Oct 19

PMID 37854546

Authors

Yizhe Zhao

Shuangchen Li

Xuelei He

Jingjing Yu

Lizhi Zhang

Heng Zhang

De Wei

Beilei Wang

Jintao Li

Hongbo Guo

Xiaowei He

Affiliations

Soon will be listed here.

Abstract

Dynamic fluorescence molecular tomography (DFMT) is a promising molecular imaging technique that offers the potential to monitor fast kinetic behaviors within small animals in three dimensions. Early monitoring of liver disease requires the ability to distinguish and analyze normal and injured liver tissues. However, the inherent ill-posed nature of the problem and energy signal interference between the normal and injured liver regions limit the practical application of liver injury monitoring. In this study, we propose a novel strategy based on time and energy, leveraging the temporal correlation in fluorescence molecular imaging (FMI) sequences and the metabolic differences between normal and injured liver tissue. Additionally, considering fluorescence signal distribution disparity between the injured and normal regions, we designed a universal Golden Ratio Primal-Dual Algorithm (GRPDA) to reconstruct both the normal and injured liver regions. Numerical simulation and experiment results demonstrate that the proposed strategy can effectively avoid signal interference between liver and liver injury energy and lead to significant improvements in morphology recovery and positioning accuracy compared to existing approaches. Our research presents a new perspective on distinguishing normal and injured liver tissues for early liver injury monitoring.

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