Computer-assisted Cognitive Rehabilitation in Neurological Patients: State-of-art and Future Perspectives

Overview

Journal Front Neurol

Specialty Neurology

Date 2023 Oct 19

PMID 37854065

Authors

Maria Grazia Maggio

Daniela De Bartolo

Rocco Salvatore Calabro

Irene Ciancarelli

Antonio Cerasa

Paolo Tonin

Fulvia Di Iulio

Stefano Paolucci

Gabriella Antonucci

Giovanni Morone

Marco Iosa

Affiliations

Soon will be listed here.

Abstract

Background And Aim: Advances in computing technology enabled researchers and clinicians to exploit technological devices for cognitive training and rehabilitation interventions. This expert review aims to describe the available software and device used for cognitive training or rehabilitation interventions of patients with neurological disorders.

Methods: A scoping review was carried out to analyze commercial devices/software for computerized cognitive training (CCT) in terms of feasibility and efficacy in both clinical and home settings. Several cognitive domains responding to the different patients' needs are covered.

Results: This review showed that cognitive training for patients with neurological diseases is largely covered by several devices that are widely used and validated in the hospital setting but with few translations to remote/home applications. It has been demonstrated that technology and software-based devices are potential and valuable tools to administer remotely cognitive rehabilitation with accessible costs.

Conclusion: According to our results, CCT entails the possibility to continue cognitive training also in different settings, such as home, which is a significant breakthrough for the improvement of community care. Other possible areas of use should be the increase in the amount of cognitive therapy in the free time during the hospital stay.

Citing Articles

Multidomain Cognitive Tele-Neurorehabilitation Training in Long-Term Post-Stroke Patients: An RCT Study.

Contrada M, Arabia G, Vatrano M, Pucci C, Mantia I, Scarfone F Brain Sci. 2025; 15(2).

PMID: 40002478 PMC: 11852918. DOI: 10.3390/brainsci15020145.

Virtual reality-based music attention training for acquired brain injury: A randomized crossover study.

Jeong E, Ham Y, Lee S, Shin J Ann N Y Acad Sci. 2024; 1541(1):151-162.

PMID: 39476208 PMC: 11580773. DOI: 10.1111/nyas.15249.

The effect of computerized cognitive training and transcranial direct current stimulation on working memory among post-stroke individuals: a systematic review with meta-analysis and meta-regression.

Kazinczi C, Kocsis K, Boross K, Racsmany M, Klivenyi P, Vecsei L BMC Neurol. 2024; 24(1):314.

PMID: 39232643 PMC: 11373461. DOI: 10.1186/s12883-024-03813-x.

The influence of eight cognitive training regimes upon cognitive screening tool performance in post-stroke survivors: a network meta-analysis.

Zhou L, Huang X, Wang J, Wang F, Liu J, Liu N Front Aging Neurosci. 2024; 16:1374546.

PMID: 39100748 PMC: 11294113. DOI: 10.3389/fnagi.2024.1374546.

Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled....

Manenti R, Baglio F, Pagnoni I, Gobbi E, Campana E, Alaimo C Front Aging Neurosci. 2024; 16:1414593.

PMID: 38966802 PMC: 11223647. DOI: 10.3389/fnagi.2024.1414593.

References

Shaker H, Sawan S, Fahmy E, Shehata Ismail R, Elrahman S . Effect of transcranial direct current stimulation on cognitive function in stroke patients. Egypt J Neurol Psychiatr Neurosurg. 2018; 54(1):32. PMC: 6223736. DOI: 10.1186/s41983-018-0037-8. View

Fadzil N, Shahar S, Rajikan R, Singh D, Mat Ludin A, Subramaniam P . A Scoping Review for Usage of Telerehabilitation among Older Adults with Mild Cognitive Impairment or Cognitive Frailty. Int J Environ Res Public Health. 2022; 19(7). PMC: 8997970. DOI: 10.3390/ijerph19074000. View

Walton C, Mowszowski L, Gilat M, Hall J, OCallaghan C, Muller A . Cognitive training for freezing of gait in Parkinson's disease: a randomized controlled trial. NPJ Parkinsons Dis. 2018; 4:15. PMC: 5959878. DOI: 10.1038/s41531-018-0052-6. View

Yoo C, Yong M, Chung J, Yang Y . Effect of computerized cognitive rehabilitation program on cognitive function and activities of living in stroke patients. J Phys Ther Sci. 2015; 27(8):2487-9. PMC: 4563296. DOI: 10.1589/jpts.27.2487. View

Diaz Baquero A, Franco-Martin M, Parra Vidales E, Toribio-Guzman J, Bueno-Aguado Y, Martinez Abad F . The Effectiveness of GRADIOR: A Neuropsychological Rehabilitation Program for People with Mild Cognitive Impairment and Mild Dementia. Results of a Randomized Controlled Trial After 4 and 12 Months of Treatment. J Alzheimers Dis. 2022; 86(2):711-727. PMC: 9028667. DOI: 10.3233/JAD-215350. View

Diaz Baquero A, Perea Bartolome M, Toribio-Guzman J, Martinez-Abad F, Parra Vidales E, Bueno Aguado Y . Determinants of Adherence to a "GRADIOR" Computer-Based Cognitive Training Program in People with Mild Cognitive Impairment (MCI) and Mild Dementia. J Clin Med. 2022; 11(6). PMC: 8955227. DOI: 10.3390/jcm11061714. View

Maggio M, De Luca R, Manuli A, Calabro R . The five 'W' of cognitive telerehabilitation in the Covid-19 era. Expert Rev Med Devices. 2020; 17(6):473-475. DOI: 10.1080/17434440.2020.1776607. View

Vilou I, Bakirtzis C, Artemiadis A, Ioannidis P, Papadimitriou M, Konstantinopoulou E . Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: an explorative study. J Integr Neurosci. 2020; 19(2):341-347. DOI: 10.31083/j.jin.2020.02.35. View

Lundqvist A, Grundstrom K, Samuelsson K, Ronnberg J . Computerized training of working memory in a group of patients suffering from acquired brain injury. Brain Inj. 2010; 24(10):1173-83. DOI: 10.3109/02699052.2010.498007. View

10.

De Luca R, Latella D, Maggio M, Di Lorenzo G, Maresca G, Sciarrone F . Computer assisted cognitive rehabilitation improves visuospatial and executive functions in Parkinson's disease: Preliminary results. NeuroRehabilitation. 2019; 45(2):285-290. DOI: 10.3233/NRE-192789. View

11.

Campbell J, Langdon D, Cercignani M, Rashid W . A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study. Neural Plast. 2017; 2016:4292585. PMC: 5223046. DOI: 10.1155/2016/4292585. View

12.

Jiang C, Yang S, Tao J, Huang J, Li Y, Ye H . Clinical Efficacy of Acupuncture Treatment in Combination With RehaCom Cognitive Training for Improving Cognitive Function in Stroke: A 2 × 2 Factorial Design Randomized Controlled Trial. J Am Med Dir Assoc. 2016; 17(12):1114-1122. DOI: 10.1016/j.jamda.2016.07.021. View

13.

Johansson B, Tornmalm M . Working memory training for patients with acquired brain injury: effects in daily life. Scand J Occup Ther. 2011; 19(2):176-83. DOI: 10.3109/11038128.2011.603352. View

14.

Yeh T, Chang K, Wu C . The Active Ingredient of Cognitive Restoration: A Multicenter Randomized Controlled Trial of Sequential Combination of Aerobic Exercise and Computer-Based Cognitive Training in Stroke Survivors With Cognitive Decline. Arch Phys Med Rehabil. 2019; 100(5):821-827. DOI: 10.1016/j.apmr.2018.12.020. View

15.

Amiri S, Hassani-Abharian P, Vaseghi S, Kazemi R, Nasehi M . Effect of RehaCom cognitive rehabilitation software on working memory and processing speed in chronic ischemic stroke patients. Assist Technol. 2021; 35(1):41-47. DOI: 10.1080/10400435.2021.1934608. View

16.

De Bartolo D, Morone G, Lupo A, Aloise F, Baricich A, Di Francesco D . From paper to informatics: the Post Soft Care-App, an easy-to-use and fast tool to help therapists identify unmet needs in stroke patients. Funct Neurol. 2019; 33(4):200-205. View

17.

De Luca R, Leonardi S, Spadaro L, Russo M, Aragona B, Torrisi M . Improving Cognitive Function in Patients with Stroke: Can Computerized Training Be the Future?. J Stroke Cerebrovasc Dis. 2017; 27(4):1055-1060. DOI: 10.1016/j.jstrokecerebrovasdis.2017.11.008. View

18.

ONeil-Pirozzi T, Hsu H . Feasibility and benefits of computerized cognitive exercise to adults with chronic moderate-to-severe cognitive impairments following an acquired brain injury: A pilot study. Brain Inj. 2016; 30(13-14):1617-1625. DOI: 10.1080/02699052.2016.1199906. View

19.

Mantovani E, Zucchella C, Bottiroli S, Federico A, Giugno R, Sandrini G . Telemedicine and Virtual Reality for Cognitive Rehabilitation: A Roadmap for the COVID-19 Pandemic. Front Neurol. 2020; 11:926. PMC: 7522345. DOI: 10.3389/fneur.2020.00926. View

20.

Fernandez E, Bergado Rosado J, Rodriguez Perez D, Salazar Santana S, Torres Aguilar M, Bringas M . Effectiveness of a Computer-Based Training Program of Attention and Memory in Patients with Acquired Brain Damage. Behav Sci (Basel). 2018; 8(1). PMC: 5791022. DOI: 10.3390/bs8010004. View