Encapsulation of Ru(II) Polypyridine Complexes for Tumor-Targeted Anticancer Therapy

Overview

Journal BME Front

Specialty Biomedical Engineering

Date 2023 Oct 18

PMID 37849670

Authors

Johannes Karges

Affiliations

Soon will be listed here.

Abstract

Ru(II) polypyridine complexes have attracted much attention as anticancer agents because of their unique photophysical, photochemical, and biological properties. Despite their promising therapeutic profile, the vast majority of compounds are associated with poor water solubility and poor cancer selectivity. Among the different strategies employed to overcome these pharmacological limitations, many research efforts have been devoted to the physical or covalent encapsulation of the Ru(II) polypyridine complexes into nanoparticles. This article highlights recent developments in the design, preparation, and physicochemical properties of Ru(II) polypyridine complex-loaded nanoparticles for their potential application in anticancer therapy.

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References

Karges J . Clinical Development of Metal Complexes as Photosensitizers for Photodynamic Therapy of Cancer. Angew Chem Int Ed Engl. 2021; 61(5):e202112236. DOI: 10.1002/anie.202112236. View

Lee S, Kim C, Nam T . Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives. Drug Des Devel Ther. 2020; 14:5375-5392. PMC: 7721113. DOI: 10.2147/DDDT.S275007. View

Zhu X, Zhou H, Liu Y, Wen Y, Wei C, Yu Q . Transferrin/aptamer conjugated mesoporous ruthenium nanosystem for redox-controlled and targeted chemo-photodynamic therapy of glioma. Acta Biomater. 2018; 82:143-157. DOI: 10.1016/j.actbio.2018.10.012. View

Oun R, Moussa Y, Wheate N . The side effects of platinum-based chemotherapy drugs: a review for chemists. Dalton Trans. 2018; 47(19):6645-6653. DOI: 10.1039/c8dt00838h. View

Liu P, Chen G, Zhang J . A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives. Molecules. 2022; 27(4). PMC: 8879473. DOI: 10.3390/molecules27041372. View

Zhao X, Li M, Sun W, Fan J, Du J, Peng X . An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells. Chem Commun (Camb). 2018; 54(51):7038-7041. DOI: 10.1039/c8cc03786h. View

Choi H, Liu W, Misra P, Tanaka E, Zimmer J, Ipe B . Renal clearance of quantum dots. Nat Biotechnol. 2007; 25(10):1165-70. PMC: 2702539. DOI: 10.1038/nbt1340. View

de Jong W, Borm P . Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine. 2008; 3(2):133-49. PMC: 2527668. DOI: 10.2147/ijn.s596. View

Liechty W, Kryscio D, Slaughter B, Peppas N . Polymers for drug delivery systems. Annu Rev Chem Biomol Eng. 2012; 1:149-73. PMC: 3438887. DOI: 10.1146/annurev-chembioeng-073009-100847. View

10.

Karges J, Tharaud M, Gasser G . Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers. J Med Chem. 2021; 64(8):4612-4622. DOI: 10.1021/acs.jmedchem.0c02006. View

11.

Li Q, Li X, Zhao C . Strategies to Obtain Encapsulation and Controlled Release of Small Hydrophilic Molecules. Front Bioeng Biotechnol. 2020; 8:437. PMC: 7237580. DOI: 10.3389/fbioe.2020.00437. View

12.

Lian T, Ho R . Trends and developments in liposome drug delivery systems. J Pharm Sci. 2001; 90(6):667-80. DOI: 10.1002/jps.1023. View

13.

Chen R, Zhang J, Chelora J, Xiong Y, Kershaw S, Li K . Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy. ACS Appl Mater Interfaces. 2017; 9(7):5699-5708. DOI: 10.1021/acsami.6b12469. View

14.

Karges J . Combination of chemistry and material science to overcome health problems. Biosaf Health. 2022; 4(2):64-65. PMC: 8906073. DOI: 10.1016/j.bsheal.2022.03.004. View

15.

Huang Y, Huang W, Chan L, Zhou B, Chen T . A multifunctional DNA origami as carrier of metal complexes to achieve enhanced tumoral delivery and nullified systemic toxicity. Biomaterials. 2016; 103:183-196. DOI: 10.1016/j.biomaterials.2016.06.053. View

16.

Karges J . Combining Inorganic Chemistry and Biology: The Underestimated Potential of Metal Complexes in Medicine. Chembiochem. 2020; 21(21):3044-3046. DOI: 10.1002/cbic.202000397. View

17.

Shen J, Kim H, Wolfram J, Mu C, Zhang W, Liu H . A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer. Nano Lett. 2017; 17(5):2913-2920. PMC: 5484597. DOI: 10.1021/acs.nanolett.7b00132. View

18.

Fu H, Chen Y, Yu Q, Liu Y . A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability. Chem Commun (Camb). 2019; 55(21):3148-3151. DOI: 10.1039/c8cc09964b. View

19.

Du E, Hu X, Roy S, Wang P, Deasy K, Mochizuki T . Taurine-modified Ru(ii)-complex targets cancerous brain cells for photodynamic therapy. Chem Commun (Camb). 2017; 53(44):6033-6036. DOI: 10.1039/c7cc03337k. View

20.

Liu J, Lai H, Xiong Z, Chen B, Chen T . Functionalization and cancer-targeting design of ruthenium complexes for precise cancer therapy. Chem Commun (Camb). 2019; 55(67):9904-9914. DOI: 10.1039/c9cc04098f. View