Continuous Shear Wave Measurements for Dynamic Cardiac Stiffness Evaluation in Pigs

Overview

Journal Sci Rep

Specialty Science

Date 2023 Oct 17

PMID 37848474

Authors

Annette Caenen

Lana Keijzer

Stephanie Bezy

Jurgen Duchenne

Marta Orlowska

Antonius F W van der Steen

Nico de Jong

Johan G Bosch

Jens-Uwe Voigt

Jan Dhooge

Hendrik J Vos

Affiliations

Soon will be listed here.

Abstract

Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tissue stiffness. This measurement is repeated multiple times across the cardiac cycle to assess the natural variations in wave propagation speed. The interpretation of these measurements remains however complex, as factors such as loading and contractility affect wave propagation. We therefore applied transthoracic shear wave elastography in 13 pigs to investigate the dependencies of wave speed on pressure-volume derived indices of loading, myocardial stiffness, and contractility, while altering loading and inducing myocardial ischemia/reperfusion injury. Our results show that diastolic wave speed correlates to a pressure-volume derived index of operational myocardial stiffness (R = 0.75, p < 0.001), suggesting that both loading and intrinsic properties can affect diastolic wave speed. Additionally, the wave speed ratio, i.e. the ratio of systolic and diastolic speed, correlates to a pressure-volume derived index of contractility, i.e. preload-recruitable stroke work (R = 0.67, p < 0.001). Measuring wave speed ratio might thus provide a non-invasive index of contractility during ischemia/reperfusion injury.

Citing Articles

Impact of loading, heart rate, and short episodes of ischaemia on myocardial stiffness assessed using shear wave elastography in an open-chest animal model.

Saloux E, Simard C, Ruello P, Lemaitre A, Hodzic A, Lebrun A Eur Heart J Imaging Methods Pract. 2025; 3(1):qyaf015.

PMID: 40041036 PMC: 11879029. DOI: 10.1093/ehjimp/qyaf015.

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