The Role of Circulating Immune Complexes in the Glomerular Disease of Experimental Hepatosplenic Schistosomiasis

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1979 Mar 1

PMID 378479

Citations 11

Authors

M DIGEON

D Droz

L H Noel

J Riza

C Rieumailhol

J F Bach

F Santoro

A Capron

Affiliations

Soon will be listed here.

Abstract

The serological and renal changes were studied simultaneously in 115 mice infected with Schistosoma mansoni. IgG and IgM, but not IgA anti-S. mansoni antibodies were detected in the sera, together with circulating immune complexes containing schistosomal antigen. Glomerular mesangial deposits of IgA, IgM and C3 were observed. Despite the strong correlation observed between the occurrence of the circulating immune complexes containing schistosomal antigen and the glomerular deposits, results concerning the behaviour of IgA suggest that portal hypertension and liver damage have a role in the pathogenesis of glomerular lesions.

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