What Are the Functions of Zinc in the Nervous System?

Overview

Journal Neurology

Specialty Neurology

Date 2023 Oct 16

PMID 37845046

Authors

Eduardo Benarroch

Affiliations

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References

Lu Q, Haragopal H, Slepchenko K, Stork C, Li Y . Intracellular zinc distribution in mitochondria, ER and the Golgi apparatus. Int J Physiol Pathophysiol Pharmacol. 2016; 8(1):35-43. PMC: 4859877. View

Sunuwar L, Gilad D, Hershfinkel M . The zinc sensing receptor, ZnR/GPR39, in health and disease. Front Biosci (Landmark Ed). 2017; 22(9):1469-1492. DOI: 10.2741/4554. View

Lin D, Cohen A, Coulter D . Zinc-induced augmentation of excitatory synaptic currents and glutamate receptor responses in hippocampal CA3 neurons. J Neurophysiol. 2001; 85(3):1185-96. DOI: 10.1152/jn.2001.85.3.1185. View

He K, Aizenman E . ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity. J Neurochem. 2010; 114(2):452-61. PMC: 2910154. DOI: 10.1111/j.1471-4159.2010.06762.x. View

Inoue K, Branigan D, Xiong Z . Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels. J Biol Chem. 2010; 285(10):7430-9. PMC: 2844191. DOI: 10.1074/jbc.M109.040485. View

Li Y, Andereggen L, Yuki K, Omura K, Yin Y, Gilbert H . Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration. Proc Natl Acad Sci U S A. 2017; 114(2):E209-E218. PMC: 5240690. DOI: 10.1073/pnas.1616811114. View

Sun A, Wu M, Vijayalingam M, Wacker M, Chu X . The Role of Zinc in Modulating Acid-Sensing Ion Channel Function. Biomolecules. 2023; 13(2). PMC: 9953155. DOI: 10.3390/biom13020229. View

Maret W . The redox biology of redox-inert zinc ions. Free Radic Biol Med. 2019; 134:311-326. DOI: 10.1016/j.freeradbiomed.2019.01.006. View

Cassandri M, Smirnov A, Novelli F, Pitolli C, Agostini M, Malewicz M . Zinc-finger proteins in health and disease. Cell Death Discov. 2017; 3:17071. PMC: 5683310. DOI: 10.1038/cddiscovery.2017.71. View

10.

Suh S, Silva D, Frederickson C, Thompson R . Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr. 2000; 130(5S Suppl):1471S-83S. DOI: 10.1093/jn/130.5.1471S. View

11.

Hou S, Vigeland L, Zhang G, Xu R, Li M, Heinemann S . Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain. J Biol Chem. 2009; 285(9):6434-42. PMC: 2825439. DOI: 10.1074/jbc.M109.069211. View

12.

Fu X, Zeng A, Zheng W, Du Y . Upregulation of zinc transporter 2 in the blood-CSF barrier following lead exposure. Exp Biol Med (Maywood). 2013; 239(2):202-12. PMC: 3928640. DOI: 10.1177/1535370213509213. View

13.

Ji S, Weiss J . Zn-induced disruption of neuronal mitochondrial function: Synergism with Ca, critical dependence upon cytosolic Zn buffering, and contributions to neuronal injury. Exp Neurol. 2018; 302:181-195. PMC: 5849513. DOI: 10.1016/j.expneurol.2018.01.012. View

14.

Lyubartseva G, Smith J, Markesbery W, Lovell M . Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain. Brain Pathol. 2009; 20(2):343-50. PMC: 3175637. DOI: 10.1111/j.1750-3639.2009.00283.x. View

15.

Ye M, Yang W, Ainscough J, Hu X, Li X, Sedo A . TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia. Cell Death Dis. 2014; 5:e1541. PMC: 4260752. DOI: 10.1038/cddis.2014.494. View

16.

Andreini C, Banci L, Bertini I, Rosato A . Counting the zinc-proteins encoded in the human genome. J Proteome Res. 2006; 5(1):196-201. DOI: 10.1021/pr050361j. View

17.

Kury S, Dreno B, Bezieau S, Giraudet S, Kharfi M, Kamoun R . Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat Genet. 2002; 31(3):239-40. DOI: 10.1038/ng913. View

18.

Grzywacz A, Gdula-Argasinska J, Muszynska B, Tyszka-Czochara M, Librowski T, Opoka W . Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level. Acta Biochim Pol. 2015; 62(3):491-8. DOI: 10.18388/abp.2015_1038. View

19.

Mitsuya K, Nitta N, Suzuki F . Persistent zinc depletion in the mossy fiber terminals in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy. Epilepsia. 2009; 50(8):1979-90. DOI: 10.1111/j.1528-1167.2009.02055.x. View

20.

Luo J, Bavencoffe A, Yang P, Feng J, Yin S, Qian A . Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain. J Neurosci. 2017; 38(2):474-483. PMC: 5761620. DOI: 10.1523/JNEUROSCI.1816-17.2017. View