Mid-term Outcomes of Surgical Aortic Valve Replacement Using a Mosaic Porcine Bioprosthesis with Concomitant Mitral Valve Repair

Overview

Journal Heart Vessels

Specialty Cardiology & Vascular Diseases

Date 2023 Oct 16

PMID 37843552

Authors

Haruhiko Sugimori

Tatsuya Nakao

Yukikatsu Okada

Yutaka Okita

Hitoshi Yaku

Junjiro Kobayashi

Hideyuki Uesugi

Shuichiro Takanashi

Toshiaki Ito

Tadaaki Koyama

Taichi Sakaguchi

Kouji Yamamoto

Yasushi Yoshikawa

Yoshiki Sawa

Affiliations

Soon will be listed here.

Abstract

This study retrospectively evaluated the mid-term outcomes of surgical aortic valve replacement (SAVR) using a stented porcine aortic valve bioprosthesis (Mosaic; Medtronic Inc., Minneapolis, MN, USA) with concomitant mitral valve (MV) repair. From 1999 to 2014, 157 patients (median [interquartile range] age, 75 [70-79] years; 47% women) underwent SAVR with concomitant MV repair (SAVR + MV repair), and 1045 patients (median [interquartile range] age, 76 [70-80] years; 54% women) underwent SAVR only at 10 centers in Japan as part of the long-term multicenter Japan Mosaic valve (J-MOVE) study. The 5-year overall survival rate was 81.5% ± 4.1% in the SAVR + MV repair group and 85.1% ± 1.4% in the SAVR only group, and the 8-year overall survival rates were 75.2% ± 5.7% and 78.1% ± 2.1%, respectively. Cox proportional hazards analysis showed no significant difference in the survival rates between the two groups (hazard ratio, 0.87; 95% confidence interval, 0.54-1.40; P = 0.576). Among women with mild or moderate mitral regurgitation who were not receiving dialysis, those who underwent SAVR + MV repair, were aged > 75 years, and had a preoperative left ventricular ejection fraction of 30-75% tended to have a lower mortality risk. In conclusion, this subgroup analysis of the J-MOVE cohort showed relevant mid-term outcomes after SAVR + MV repair.

Citing Articles

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PMID: 39860521 PMC: 11765876. DOI: 10.3390/jcm14020515.

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