Role of Pattern Recognition Receptors in Sensing

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Oct 16

PMID 37842564

Authors

S M Neamul Kabir Zihad

Nazifa Sifat

Mohammad Ashraful Islam

A S M Monjur-Al-Hossain

K M Yasif Kayes Sikdar

Md Moklesur Rahman Sarker

Jamil A Shilpi

Shaikh Jamal Uddin

Affiliations

Soon will be listed here.

Abstract

is one of the major invasive intracellular pathogens causing most deaths by a single infectious agent. The interaction between host immune cells and this pathogen is the focal point of the disease, Tuberculosis. Host immune cells not only mount the protective action against this pathogen but also serve as the primary niche for growth. Thus, recognition of this pathogen by host immune cells and following signaling cascades are key dictators of the disease state. Immune cells, mainly belonging to myeloid cell lineage, recognize a wide variety of ligands ranging from carbohydrate and lipids to proteins to nucleic acids by different membrane-bound and soluble pattern recognition receptors. Simultaneous interaction between different host receptors and pathogen ligands leads to immune-inflammatory response as well as contributes to virulence. This review summarizes the contribution of pattern recognition receptors of host immune cells in recognizing and subsequent initiation of signaling pathways to provide the molecular insight of the specific Mtb ligands interacting with specific PRR, key adaptor molecules of the downstream signaling pathways and the resultant effector functions which will aid in identifying novel drug targets, and developing novel drugs and adjuvants.

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