The Multifaceted Role of Extracellular Vesicles in Prostate Cancer-a Review

Overview

Journal Cancer Drug Resist

Date 2023 Oct 16

PMID 37842237

Authors

Divya Prakash Jain

Yirivinti Hayagreeva Dinakar

Hitesh Kumar

Rupshee Jain

Vikas Jain

Affiliations

Soon will be listed here.

Abstract

Prostate cancer is the second most prominent form of cancer in men and confers the highest mortality after lung cancer. The term "extracellular vesicles" refers to minute endosomal-derived membrane microvesicles and it was demonstrated that extracellular vesicles affect the environment in which tumors originate. Extracellular vesicles' involvement is also established in the development of drug resistance, angiogenesis, stemness, and radioresistance in various cancers including prostate cancer. Extracellular vesicles influence the general environment, processes, and growth of prostate cancer and can be a potential area that offers a significant lead in prostate cancer therapy. In this review, we have elaborated on the multifaceted role of extracellular vesicles in various processes involved in the development of prostate cancer, and their multitude of applications in the diagnosis and treatment of prostate cancer through the encapsulation of various bioactives.

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