The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis

Overview

Journal J Inflamm Res

Publisher Dove Medical Press

Date 2023 Oct 16

PMID 37842190

Authors

Pengcheng Jiao

Zuntai Li

Birong Li

Xingyuan Jiao

Affiliations

Soon will be listed here.

Abstract

Peri-implantitis is an important cause of oral implant failure. In the past, TLR4 and TLR2 in the Toll-like family were generally considered as the key immune recognition receptors regulating peri-implantitis. However, under the guidance of this theory, there are still some unexplainable peri-implantitis symptoms. With the discovery of novel intracellular LPS receptor Caspase-11, a new understanding of inflammatory signaling and immune regulation in the development of peri-implantitis has been gained. However, the regulatory role of Caspase-11 in peri-implantitis and its crosstalk with the TLR4 pathway remain unclear. The therapeutic effect of drugs targeting Caspase-11 on peri-implantitis is still in its early stages. In view of this situation, this paper reviews the possible role of Caspase-11 in peri-implant inflammation, elaborated the entry process of LPS and the activation mechanism of Caspase-11, and analyzes the differences in Caspase-11 between commonly studied animals, mice and humans. The current research hotspots and challenges are also analyzed to provide new insights and ideas for researchers.

Citing Articles

The Oral Microbiome of Peri-Implant Health and Disease: A Narrative Review.

Kajimoto N, de Paiva Buischi Y, Mohamadzadeh M, Loomer P Dent J (Basel). 2024; 12(10).

PMID: 39452426 PMC: 11506630. DOI: 10.3390/dj12100299.

Bacterial species associated with peri-implant disease - a literature review.

Sandulescu M, Sirbu V, Popovici I Germs. 2024; 13(4):352-361.

PMID: 38361546 PMC: 10866163. DOI: 10.18683/germs.2023.1405.

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