Negligible Effect of Vitamin D Supplementation on Exacerbation in Patients with Chronic Obstructive Pulmonary Disease: Meta-analysis

Overview

Journal Biochem Med (Zagreb)

Specialty Biochemistry

Date 2023 Oct 16

PMID 37841773

Authors

Ye Hua

Ting Jiang

Jiangyi Feng

Mi Zou

Affiliations

Soon will be listed here.

Abstract

Introduction: The focus of this meta-analysis was how vitamin D supplementation influences exacerbations in patients with chronic obstructive pulmonary disease (COPD) and vitamin D deficiency (VDD).

Materials And Methods: Cochrane Library, Web of Science, Embase, and PubMed databases have been systematically searched in an attempt to collect randomized controlled trials related to vitamin D supplementation in COPD patients with VDD published in English available by July 2022. Primary outcome indicators included the mean number of exacerbation and rate of exacerbation. Secondary outcome indicators included forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC) ratio, and serum 25-hydroxyvitamin D (25(OH)D) concentration.

Results: Five studies involving 522 COPD patients with VDD (defined as 25(OH)D < 50 nmol/L) were included, among them 61 were severely deficient in vitamin D (25(OH)D < 25 nmol/L). The results showed that vitamin D supplementation did not decrease the mean number of exacerbation (standardized mean difference (SMD): - 0.10, 95% CI: - 0.29 to 0.09) and the rate of exacerbation (relative risk (RR): 0.89, 95% CI: 0.76 to 1.04, P = 0.179). Also, its effect on FEV1 (SMD: - 0.06, 95% CI: - 0.30 to 0.17) and FEV1/FVC (SMD: -0.10, 95% CI: - 0.48 to 0.27) remained negligible. However, it could increase the serum 25(OH)D concentration (SMD: 2.44, 95 CI%: 2.20 to 2.68, P < 0.001).

Conclusions: The effects of vitamin D supplementation on decreasing exacerbation and improving pulmonary function were not significant.

Citing Articles

Vitamin D Supplementation: A Review of the Evidence Arguing for a Daily Dose of 2000 International Units (50 µg) of Vitamin D for Adults in the General Population.

Pludowski P, Grant W, Karras S, Zittermann A, Pilz S Nutrients. 2024; 16(3).

PMID: 38337676 PMC: 10857599. DOI: 10.3390/nu16030391.

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