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Liver Transplantation for Primary Sclerosing Cholangitis (PSC) With or Without Inflammatory Bowel Disease (IBD)-A European Society of Organ Transplantation (ESOT) Consensus Statement

Abstract

Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD) and a lead indication for liver transplantation (LT) in the western world. In this article, we present a Consensus Statement on LT practice, developed by a dedicated Guidelines' Taskforce of the European Society of Organ Transplantation (ESOT). The overarching goal is to provide practical guidance on commonly debated topics, including indications and timing of LT, management of bile duct stenosis in patients on the transplant waiting list, technical aspects of transplantation, immunosuppressive strategies post-transplant, timing and extension of intestinal resection and futility criteria for re-transplantation.

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References
1.
Carbone M, Neuberger J . Autoimmune liver disease, autoimmunity and liver transplantation. J Hepatol. 2013; 60(1):210-23. DOI: 10.1016/j.jhep.2013.09.020. View

2.
Lightner A, Shen B . Perioperative use of immunosuppressive medications in patients with Crohn's disease in the new "biological era". Gastroenterol Rep (Oxf). 2017; 5(3):165-177. PMC: 5554387. DOI: 10.1093/gastro/gow046. View

3.
Ferreira M, Ribeiro I, Hourneaux de Moura D, McCarty T, da Ponte Neto A, Farias G . Stent versus Balloon Dilation for the Treatment of Dominant Strictures in Primary Sclerosing Cholangitis: A Systematic Review and Meta-Analysis. Clin Endosc. 2021; 54(6):833-842. PMC: 8652153. DOI: 10.5946/ce.2021.052. View

4.
Olsson R, Bjornsson E, Backman L, Friman S, Hockerstedt K, Kaijser B . Bile duct bacterial isolates in primary sclerosing cholangitis: a study of explanted livers. J Hepatol. 1998; 28(3):426-32. DOI: 10.1016/s0168-8278(98)80316-4. View

5.
Goss J, Shackleton C, Farmer D, Arnaout W, Seu P, Markowitz J . Orthotopic liver transplantation for primary sclerosing cholangitis. A 12-year single center experience. Ann Surg. 1997; 225(5):472-81; discussion 481-3. PMC: 1190779. DOI: 10.1097/00000658-199705000-00004. View