Sleep-inducing Effect of Rhynchophylline in Knockout Mice

Overview

Journal Sleep Adv

Date 2023 Oct 16

PMID 37840649

Authors

Maria Neus Ballester Roig

Valerie Mongrain

Affiliations

Soon will be listed here.

Abstract

We have recently demonstrated that the alkaloid rhynchophylline (RHY; purified from plants) induces sleep and modifies electrocorticographic (ECoG) activity throughout the 24-h day in a vigilance state-dependent manner in wild-type mice. We here asked whether this alkaloid impacts wake/sleep variables in the absence of the cell adhesion protein EPHA4, via ECoG recording in knockout (KO) mice submitted to the same RHY treatment contemporaneously to the wild-type mice (littermates). We uncover that RHY decreases time spent awake and increases time spent in slow wave sleep in KO mice and alters the 24-h time course of ECoG activity during wakefulness and sleep states. These observations are similar to the reported effects of RHY in wild-type littermate animals, which strongly supports that RHY-driven sleep alterations are not dependent on the presence of EPHA4.

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