Does Occupational Radiation Exposure Affect Retinal Nerve Fiber Thickness?

Overview

Journal Int Ophthalmol

Specialty Ophthalmology

Date 2023 Oct 15

PMID 37840074

Authors

Hakan Koc

Serkan Ozen

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate the thickness of peripapillary nerve fibers in radiation-exposed healthcare workers.

Methods: The study included 60 radiation-exposed healthcare workers and 60 healthy control groups. SD-OCT was used to measure mean peripapillary RNFL thickness along with peripapillary RNFL thickness in the upper, lower, nasal, and temporal quadrants.

Results: The mean age of the subjects participating in the study was 37 ± 6.3 (range 25-50) in the radiation-exposed group and 38 ± 4.9 (range 26-48) in the control group. The mean duration of exposure to radiation in healthcare workers was 11 ± 5 years (range 5-27). While the mean total rim thickness was 94.25 ± 8.2 in the radiation-exposed group, it was 102.8 ± 7.4 in the control group (p < 0.001). The mean superior rim thickness was 123.93 ± 15.13 in the radiation-exposed group, while it was measured as 129.75 ± 14.64 in the control group (p = 0.34). While the mean inferior rim thickness was 110.88 ± 13.43 in the group exposed to radiation, it was 130.08 ± 13.44 in the control group (p < 0.001). The mean nasal rim thickness was 70.25 ± 9.50 in the group exposed to radiation, while it was 75.38 ± 13.77 in the control group (p = 0.46). While the mean temporal rim thickness was 71.77 ± 8.73 in the group exposed to radiation, it was measured as 75.78 ± 13.15 in the control group (p = 0.52). Significant thinning of nerve fiber thickness was found statistically significant in all and especially the inferior quadrants of the healthcare workers exposed to radiation compared to the control group.

Conclusion: After at least 5 years of radiation exposure, the thickness of the peripapillary retinal nerve fibers may decrease in healthcare workers.

References

Nuzzi R, Trossarello M, Bartoncini S, Marolo P, Franco P, Mantovani C . Ocular Complications After Radiation Therapy: An Observational Study. Clin Ophthalmol. 2020; 14:3153-3166. PMC: 7555281. DOI: 10.2147/OPTH.S263291. View

Loganovsky K, Marazziti D, Fedirko P, Kuts K, Antypchuk K, Perchuk I . Radiation-Induced Cerebro-Ophthalmic Effects in Humans. Life (Basel). 2020; 10(4). PMC: 7235763. DOI: 10.3390/life10040041. View

Wang W, Yang H, Guo L, Su H, Wei S, Zhang X . Radiation-induced optic neuropathy following external beam radiation therapy for nasopharyngeal carcinoma: A retrospective case-control study. Mol Clin Oncol. 2016; 4(5):868-872. PMC: 4840646. DOI: 10.3892/mco.2016.787. View

Li J, Yuan N, Chu W, Cheung C, Tang S, Li F . Exposure to Secondhand Smoke in Children is Associated with a Thinner Retinal Nerve Fiber Layer: The Hong Kong Children Eye Study. Am J Ophthalmol. 2020; 223:91-99. DOI: 10.1016/j.ajo.2020.10.016. View

Danesh-Meyer H . Radiation-induced optic neuropathy. J Clin Neurosci. 2007; 15(2):95-100. DOI: 10.1016/j.jocn.2007.09.004. View

Guy J, Mancuso A, Quisling R, Beck R, MOSTER M . Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies. Ophthalmology. 1990; 97(5):592-9; discussion 599-600. View

Hayreh S . The 1994 Von Sallman Lecture. The optic nerve head circulation in health and disease. Exp Eye Res. 1995; 61(3):259-72. DOI: 10.1016/s0014-4835(05)80121-6. View

Durkin S, Roos D, Higgs B, Casson R, Selva D . Ophthalmic and adnexal complications of radiotherapy. Acta Ophthalmol Scand. 2007; 85(3):240-50. DOI: 10.1111/j.1600-0420.2006.00822.x. View

Baumann M, Gentile R, Liebmann J, Ritch R . Reproducibility of retinal thickness measurements in normal eyes using optical coherence tomography. Ophthalmic Surg Lasers. 1998; 29(4):280-5. View

10.

Abri Aghdam K, Soltan Sanjari M, Farsani M, Moghadasi M, Aghajani A . Necrosis of the optic nerve and chiasm with safe radiation doses: Report of two rare cases. Eur J Ophthalmol. 2021; 32(3):NP28-NP32. DOI: 10.1177/1120672121990570. View

11.

Peeler C, Cestari D . Radiation optic neuropathy and retinopathy with low dose (20 Gy) radiation treatment. Am J Ophthalmol Case Rep. 2018; 3:50-53. PMC: 5757416. DOI: 10.1016/j.ajoc.2016.06.008. View

12.

Mazrani W, McHugh K, Marsden P . The radiation burden of radiological investigations. Arch Dis Child. 2007; 92(12):1127-31. PMC: 2066089. DOI: 10.1136/adc.2006.101782. View