Therapeutic Potential of Natural Products in the Treatment of

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Oct 14

PMID 37836650

Authors

Carine Machado Azevedo

Cassio Santana Meira

Jaqueline Wang da Silva

Danielle Maria Nascimento Moura

Sheilla Andrade de Oliveira

Cicero Jadson da Costa

Emanuelle de Souza Santos

Milena Botelho Pereira Soares

Affiliations

Soon will be listed here.

Abstract

It is estimated that 250 million people worldwide are affected by schistosomiasis. Disease transmission is related to the poor sanitation and hygiene habits that affect residents of impoverished regions in tropical and subtropical countries. The main species responsible for causing disease in humans are , , and , each with different geographic distributions. Praziquantel is the drug predominantly used to treat this disease, which offers low effectiveness against immature and juvenile parasite forms. In addition, reports of drug resistance prompt the development of novel therapeutic approaches. Natural products represent an important source of new compounds, especially those obtained from plant sources. This review compiles data from several in vitro and in vivo studies evaluating various compounds and essential oils derived from plants with cercaricidal and molluscicidal activities against both juvenile and adult forms of the parasite. Finally, this review provides an important discussion on recent advances in molecular and computational tools deemed fundamental for more rapid and effective screening of new compounds, allowing for the optimization of time and resources.

Citing Articles

Chemical Control of Snail Vectors as an Integrated Part of a Strategy for the Elimination of Schistosomiasis-A Review of the State of Knowledge and Future Needs.

Djirmay A, Yadav R, Guo J, Rollinson D, Madsen H Trop Med Infect Dis. 2024; 9(9).

PMID: 39330911 PMC: 11435910. DOI: 10.3390/tropicalmed9090222.

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