The Nematode Parasite is Pathogenic to Larvae Without Activating Their Immune Response

Entomopathogenic nematodes are commonly used to control insect pest populations in the field. They also contribute substantially to understanding the molecular basis of nematode pathogenicity and insect anti-nematode immunity. Here, we tested the effect of the entomopathogenic nematode on the survival and immune signaling regulation of wild type larvae. Our results indicate that infective juveniles are pathogenic toward larvae, but they fail to activate certain immune pathway readout genes. These findings imply that employs mechanisms that allow these parasitic nematodes to interfere with the immune system.