Proteomic Analysis of Neonatal Mouse Hearts Shows PKA Functions As a Cardiomyocyte Replication Regulator

Overview

Journal Proteome Sci

Publisher Biomed Central

Date 2023 Oct 11

PMID 37821903

Authors

Lizhi Hu

Minglu Liang

Qin Jiang

Youming Jie

Long Chen

Fengxiao Zhang

Affiliations

Soon will be listed here.

Abstract

The ability of the adult mammalian heart to regenerate can save the cardiac muscle from a loss of function caused by injury. Cardiomyocyte regeneration is a key aspect of research for the treatment of cardiovascular diseases. The mouse heart shows temporary regeneration in the first week after birth; thus, the newborn mouse heart is an ideal model to study heart muscle regeneration. In this study, proteomic analysis was used to investigate the differences in protein expression in the hearts of neonatal mice at days 1 (P1 group), 4 (P4 group), and 7 (P7 group). Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed changes in several groups of proteins, including the protein kinase A (PKA) signaling pathway. Moreover, it was found that PKA inhibitors and agonists regulated cardiomyocyte replication in neonatal mouse hearts. These findings suggest that PKA may be a target for the regulation of the cardiomyocyte cell cycle.

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