H19 Encourages Aerobic Glycolysis and Cell Growth in Gastric Cancer Cells Through the Axis of MicroRNA-19a-3p and Phosphoglycerate Kinase 1

Overview

Journal Sci Rep

Specialty Science

Date 2023 Oct 11

PMID 37821504

Authors

Siche Chen

Haiping Wang

Peiren Xu

Shengchun Dang

Yongqin Tang

Affiliations

Soon will be listed here.

Abstract

Numerous studies have been conducted on long non-coding RNAs (lncRNAs) in human tumors like gastric cancer (GC). Our research uncovers how aerobic glycolysis and cell proliferation in gastric cancer cells are related to H19. We discovered that H19 was highly expressed in tumor tissues and that patients with higher H19 expression have a poorer prognosis. Intriguingly, we applied the subcellular isolation, luciferase reporter, western blot analysis, MTT, colony formation experiments, and CDX Model in Mice to verify that H19 regulates aerobic glycolysis towards GC cell growth by H19/microRNA (miR)-19a-3p/phosphoglycerate kinase 1 (PGK1) axis. Together, our research offers proof that the H19/miR-19a-3p/PGK1 pathway aids in the regulation of aerobic glycolysis and cell proliferation in GC. This may offer an opportunity for novel therapeutic approaches to the treatment of GC.

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