Suppression of Sweet Taste-related Responses by Plant-derived Bioactive Compounds and Eating. Part I: A Systematic Review in Humans

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Oct 11

PMID 37817998

Authors

Raquel Rayo-Morales

Antonio Segura-Carretero

Isabel Borras-Linares

David Garcia-Burgos

Affiliations

Soon will be listed here.

Abstract

The taste of food plays a crucial role in determining what and how much we eat. Thus, interventions that temporarily block sweet taste receptors offer a promising approach to addressing unhealthy behaviours associated with sugary foods. However, the relationship between reduced sweet taste response and food consumption remains unclear, with contradictory findings. Certain studies suggest that a diminished perception of sweetness leads to a sense of fullness and results in reduced food intake, while others suggest the opposite effect. To shed some light, our systematic review looked into the relationship between diminished sweet taste response and food consumption by examining the effects of bioactive compounds that experimentally inhibit sweetness in healthy individuals. This review was registered in the International Prospective Register of Systematic Reviews and conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Scottish Intercollegiate Guidelines Network, and covered original papers included in Web of Science, PubMed, Scopus, Food Science Source and Food Science and technology abstracts. We identified 33 peer-reviewed English-language studies that fit the topic and met the inclusion criteria. The current literature predominantly focuses on the immediate impact of oral gymnemic acids, failing to provide preliminary evidence in support of the specific threshold hypothesis, above which food consumption decreases and below which the opposite effect occurs. Additionally, there was inconsistency in the findings regarding the short-term desire to eat following sweetness inhibition. Considering the downstream effects on energy intake and their clinical applications, further research is needed to clarify both the acute within-session effects (i.e., not wanting any more now) and the longer-term effects (i.e., deciding not to start eating) linked to oral sweet-taste-suppressing compounds.

References

Yoshikawa K, Nagai Y, Yoshida M, Arihara S . Antisweet natural products. VIII. Structures of hodulosides VI--X from Hovenia dulcis Thunb. var. tomentella Makino. Chem Pharm Bull (Tokyo). 1993; 41(10):1722-5. DOI: 10.1248/cpb.41.1722. View

Bartoshuk L, Duffy V, Hayes J, Moskowitz H, Snyder D . Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. Philos Trans R Soc Lond B Biol Sci. 2006; 361(1471):1137-48. PMC: 1642698. DOI: 10.1098/rstb.2006.1853. View

Kashima H, Eguchi K, Miyamoto K, Fujimoto M, Yamaoka Endo M, Aso-Someya N . Suppression of Oral Sweet Taste Sensation with Gymnema sylvestre Affects Postprandial Gastrointestinal Blood Flow and Gastric Emptying in Humans. Chem Senses. 2017; 42(4):295-302. DOI: 10.1093/chemse/bjw126. View

Gaspar P, Bessa F, Antunes Meireles P, Parreira I, Mota C . Sweet Taste Dysgeusia in a Patient with Indapamide-Related Hyponatremia: Case Report and Review of the Literature. Cureus. 2021; 13(2):e13079. PMC: 7931776. DOI: 10.7759/cureus.13079. View

Ventura A, Mennella J . Innate and learned preferences for sweet taste during childhood. Curr Opin Clin Nutr Metab Care. 2011; 14(4):379-84. DOI: 10.1097/MCO.0b013e328346df65. View

Treesukosol Y, Smith K, Spector A . The functional role of the T1R family of receptors in sweet taste and feeding. Physiol Behav. 2011; 105(1):14-26. PMC: 3186843. DOI: 10.1016/j.physbeh.2011.02.030. View

Rohde K, Schamarek I, Bluher M . Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?. Diabetes Metab J. 2020; 44(4):509-528. PMC: 7453985. DOI: 10.4093/dmj.2020.0058. View

Warren R, PFAFFMANN C . Suppression of sweet sensitivity by potassium gymnemate. J Appl Physiol. 1959; 14(1):40-2. DOI: 10.1152/jappl.1959.14.1.40. View

Merkonidis C, Grosse F, Ninh T, Hummel C, Haehner A, Hummel T . Characteristics of chemosensory disorders--results from a survey. Eur Arch Otorhinolaryngol. 2014; 272(6):1403-16. DOI: 10.1007/s00405-014-3210-4. View

10.

Yoshikawa K, Mizutani A, Kan Y, Arihara S . Antisweet natural products. XII. Structures of sitakisosides XI-XX from Stephanotis lutchuensis Koidz. var. japonica. Chem Pharm Bull (Tokyo). 1997; 45(1):62-7. DOI: 10.1248/cpb.45.62. View

11.

Lamey P, Darwazeh A, Frier B . Oral disorders associated with diabetes mellitus. Diabet Med. 1992; 9(5):410-6. DOI: 10.1111/j.1464-5491.1992.tb01809.x. View

12.

Frank J, Fukagawa N, Bilia A, Johnson E, Kwon O, Prakash V . Terms and nomenclature used for plant-derived components in nutrition and related research: efforts toward harmonization. Nutr Rev. 2019; 78(6):451-458. PMC: 7212822. DOI: 10.1093/nutrit/nuz081. View

13.

Meiselman H, Halpern B, Dateo G . Reduction of sweetness judgements by extracts from the leaves of Ziziphus jujuba. Physiol Behav. 1976; 17(2):313-7. DOI: 10.1016/0031-9384(76)90081-0. View

14.

Sigoillot M, Brockhoff A, Meyerhof W, Briand L . Sweet-taste-suppressing compounds: current knowledge and perspectives of application. Appl Microbiol Biotechnol. 2012; 96(3):619-30. DOI: 10.1007/s00253-012-4387-3. View

15.

Warren R, Warren R, Weninger M . Inhibition of the sweet taste by Gymnema sylvestre. Nature. 1969; 223(5201):94-5. DOI: 10.1038/223094a0. View

16.

Yoshikawa K, Hirai H, Tanaka M, Arihara S . Antisweet natural products. XV. Structures of Jegosaponins A-D from Styrax japonica Sieb. et Zucc. Chem Pharm Bull (Tokyo). 2000; 48(7):1093-6. DOI: 10.1248/cpb.48.1093. View

17.

Sukumaran S, Yee K, Iwata S, Kotha R, Quezada-Calvillo R, Nichols B . Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides. Proc Natl Acad Sci U S A. 2016; 113(21):6035-40. PMC: 4889361. DOI: 10.1073/pnas.1520843113. View

18.

Berthoud H, Morrison C, Ackroff K, Sclafani A . Learning of food preferences: mechanisms and implications for obesity & metabolic diseases. Int J Obes (Lond). 2021; 45(10):2156-2168. PMC: 8455326. DOI: 10.1038/s41366-021-00894-3. View

19.

Kurihara Y . Antisweet activity of gymnemic acid A1 and its derivatives. Life Sci. 1969; 8(9):537-43. DOI: 10.1016/0024-3205(69)90449-4. View

20.

Serrano J, Seflova J, Park J, Pribadi M, Sanematsu K, Shigemura N . The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans. Mol Metab. 2021; 54:101339. PMC: 8476773. DOI: 10.1016/j.molmet.2021.101339. View