Protective Roles and Therapeutic Effects of Gallic Acid in the Treatment of Cardiovascular Diseases: Current Trends and Future Directions

Overview

Journal Curr Med Chem

Publisher Bentham Science Publishers

Specialty Chemistry

Date 2023 Oct 10

PMID 37815180

Authors

Zahra Momeni

Sepideh Danesh

Mahsa Ahmadpour

Reza Eshraghi

Tahereh Farkhondeh

Mohammad Hossein Pourhanifeh

Saeed Samarghandian

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases (CVDs) are serious life-threatening illnesses and significant problematic issues for public health having a heavy economic burden on all society worldwide. The high incidence of these diseases as well as high mortality rates make them the leading causes of death and disability. Therefore, finding novel and more effective therapeutic methods is urgently required. Gallic acid, an herbal medicine with numerous biological properties, has been utilized in the treatment of various diseases for thousands of years. It has been demonstrated that gallic acid possesses pharmacological potential in regulating several molecular and cellular processes such as apoptosis and autophagy. Moreover, gallic acid has been investigated in the treatment of CVDs both in vivo and in vitro. Herein, we aimed to review the available evidence on the therapeutic application of gallic acid for CVDs including myocardial ischemia-reperfusion injury and infarction, drug-induced cardiotoxicity, hypertension, cardiac fibrosis, and heart failure, with a focus on underlying mechanisms.

Citing Articles

Food Components in Health Promotion and Disease Prevention.

Chiavaroli A, Brunetti L Foods. 2023; 12(24).

PMID: 38137205 PMC: 10743150. DOI: 10.3390/foods12244401.

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