Ferroptosis, Autophagy, Tumor and Immunity

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Oct 9

PMID 37810047

Authors

Yuyan Xie

Yang Zhou

Jiale Wang

Lijuan Du

Yuanyuan Ren

Fang Liu

Affiliations

Soon will be listed here.

Abstract

Ferroptosis was first proposed in 2012, a new form of cell death. Autophagy plays a crucial role in cell clearance and maintaining homeostasis. Autophagy is involved in the initial step of ferroptosis under the action of histone elements such as NCOA4, RAB7A, and BECN1. Ferroptosis and autophagy are involved in tumor progression, treatment, and drug resistance in the tumor microenvironment. In this review, we described the mechanisms of ferroptosis, autophagy, and tumor and immunotherapy, respectively, and emphasized the relationship between autophagy-related ferroptosis and tumor.

Citing Articles

Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies.

Guo D, Cai S, Deng L, Xu W, Fu S, Lin Y MedComm (2020). 2025; 6(3):e70116.

PMID: 39991627 PMC: 11847630. DOI: 10.1002/mco2.70116.

Study of an N6-methyladenosine- and ferroptosis-related prognostic model and the mechanisms underlying the molecular network in neuroblastoma based on multiple datasets.

Chu J Discov Oncol. 2025; 16(1):200.

PMID: 39964621 PMC: 11836251. DOI: 10.1007/s12672-025-01975-9.

Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets.

Gao G, Zhang X Front Immunol. 2025; 16:1542844.

PMID: 39917300 PMC: 11799241. DOI: 10.3389/fimmu.2025.1542844.

A window into intracellular events in myositis through subcellular proteomics.

Peterson J, Leclair V, Oyebode O, Herzallah D, Nestor-Kalinoski A, Morais J Inflamm Res. 2025; 74(1):31.

PMID: 39890639 PMC: 11785624. DOI: 10.1007/s00011-025-01996-8.

A crosstalk between autophagy and apoptosis in intracerebral hemorrhage.

Wang M, Chen X, Li S, Wang L, Tang H, Pu Y Front Cell Neurosci. 2024; 18:1445919.

PMID: 39650799 PMC: 11622039. DOI: 10.3389/fncel.2024.1445919.

References

Wang X, Chen Y, Wang X, Tian H, Wang Y, Jin J . Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11. Cancer Res. 2021; 81(20):5217-5229. PMC: 8530936. DOI: 10.1158/0008-5472.CAN-21-0567. View

Wang Y, Chang S, Wu Q, Gou Y, Jia L, Cui Y . The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis. Front Aging Neurosci. 2017; 8:308. PMC: 5167726. DOI: 10.3389/fnagi.2016.00308. View

Strohecker A, Guo J, Karsli-Uzunbas G, Price S, Chen G, Mathew R . Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov. 2013; 3(11):1272-85. PMC: 3823822. DOI: 10.1158/2159-8290.CD-13-0397. View

Hurley J, Young L . Mechanisms of Autophagy Initiation. Annu Rev Biochem. 2017; 86:225-244. PMC: 5604869. DOI: 10.1146/annurev-biochem-061516-044820. View

Ye L, Chaudhary K, Zandkarimi F, Harken A, Kinslow C, Upadhyayula P . Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers. ACS Chem Biol. 2020; 15(2):469-484. PMC: 7180072. DOI: 10.1021/acschembio.9b00939. View

Bryant K, Stalnecker C, Zeitouni D, Klomp J, Peng S, Tikunov A . Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nat Med. 2019; 25(4):628-640. PMC: 6484853. DOI: 10.1038/s41591-019-0368-8. View

Shen L, Zhou Y, He H, Chen W, Lenahan C, Li X . Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment. Oxid Med Cell Longev. 2021; 2021:8865791. PMC: 7889336. DOI: 10.1155/2021/8865791. View

Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q . Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A. 2008; 105(49):19211-6. PMC: 2592986. DOI: 10.1073/pnas.0810452105. View

Xie H, Zhou L, Liu F, Long J, Yan S, Xie Y . Autophagy induction regulates aquaporin 3-mediated skin fibroblast ageing. Br J Dermatol. 2021; 186(2):318-333. DOI: 10.1111/bjd.20662. View

10.

Vinogradova E, Zhang X, Remillard D, Lazar D, Suciu R, Wang Y . An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020; 182(4):1009-1026.e29. PMC: 7775622. DOI: 10.1016/j.cell.2020.07.001. View

11.

Liao M, Qin R, Huang W, Zhu H, Peng F, Han B . Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies. J Hematol Oncol. 2022; 15(1):44. PMC: 9006445. DOI: 10.1186/s13045-022-01260-0. View

12.

Girotti A, Korytowski W . Cholesterol Hydroperoxide Generation, Translocation, and Reductive Turnover in Biological Systems. Cell Biochem Biophys. 2017; 75(3-4):413-419. PMC: 5651211. DOI: 10.1007/s12013-017-0799-0. View

13.

Obba S, Hizir Z, Boyer L, Selimoglu-Buet D, Pfeifer A, Michel G . The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy. 2015; 11(7):1114-29. PMC: 4590592. DOI: 10.1080/15548627.2015.1034406. View

14.

Jin Y, Bai Y, Ni H, Qiang L, Ye L, Shan Y . Activation of autophagy through calcium-dependent AMPK/mTOR and PKCθ pathway causes activation of rat hepatic stellate cells under hypoxic stress. FEBS Lett. 2016; 590(5):672-82. DOI: 10.1002/1873-3468.12090. View

15.

Huang C, Yang M, Deng J, Li P, Su W, Jiang R . Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells. Oncol Rep. 2018; 40(4):2363-2370. DOI: 10.3892/or.2018.6585. View

16.

Levine B, Kroemer G . Biological Functions of Autophagy Genes: A Disease Perspective. Cell. 2019; 176(1-2):11-42. PMC: 6347410. DOI: 10.1016/j.cell.2018.09.048. View

17.

Pohl C, Dikic I . Cellular quality control by the ubiquitin-proteasome system and autophagy. Science. 2019; 366(6467):818-822. DOI: 10.1126/science.aax3769. View

18.

Costa Da Silva M, Breckwoldt M, Vinchi F, Correia M, Stojanovic A, Thielmann C . Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages. Front Immunol. 2017; 8:1479. PMC: 5682327. DOI: 10.3389/fimmu.2017.01479. View

19.

Koppula P, Zhang Y, Zhuang L, Gan B . Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (Lond). 2018; 38(1):12. PMC: 5993148. DOI: 10.1186/s40880-018-0288-x. View

20.

Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S . Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility. J Biol Chem. 2015; 290(23):14668-78. PMC: 4505533. DOI: 10.1074/jbc.M115.656363. View