Premature Centromere Division Dominantly Inherited in a Subfertile Family

Overview

Journal Cytogenet Cell Genet

Publisher Karger

Specialty Genetics

Date 1986 Jan 1

PMID 3780318

Citations 13

Authors

J Gabarron

A Jimenez

G Glover

Affiliations

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Abstract

An increased frequency of mitoses showing premature centromere division (PCD) in every chromosome was found in lymphocyte cultures from four members of a subfertile family. These cells were observed in both the presence and absence of colchicine. Cultured fibroblasts from the proband showed only normal diploid metaphases. PCD cells seemed to have a shorter cell cycle. The anomaly was transmitted in a way compatible with autosomal dominant inheritance in this family.

Citing Articles

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MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes.

Mailhes J, Hilliard C, Lowery M, London S Cell Chromosome. 2002; 1(1):2.

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The effects of age and abnormal sperm count on the nondisjunction of spermatozoa.

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"Premature anaphase" in a couple with recurrent miscarriages.

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