Adolescent Intermittent Alcohol Exposure Produces Strain-specific Cross-sensitization to Nicotine and Other Behavioral Adaptations in Adulthood in C57BL/6J and DBA/2J Mice

Overview

Journal Pharmacol Biochem Behav

Publisher Elsevier

Specialties Biochemistry
Pharmacology
Psychology
Social Sciences

Date 2023 Oct 6

PMID 37802393

Authors

Laurel R Seemiller

Prescilla Garcia-Trevizo

Carlos Novoa

Lisa R Goldberg

Samantha Murray

Thomas J Gould

Affiliations

Soon will be listed here.

Abstract

Adolescent alcohol exposure is associated with lasting behavioral changes in humans and in mice. Prior work from our laboratory and others have demonstrated that C57BL/6J and DBA/2J mice differ in sensitivity to some effects of acute alcohol exposure during adolescence and adulthood. However, it is unknown if these strains differ in cognitive, anxiety-related, and addiction-related long-term consequences of adolescent intermittent alcohol exposure. This study examined the impact of a previously validated adolescent alcohol exposure paradigm (2-3 g/kg, i.p., every other day PND 30-44) in C57BL/6J and DBA/2J male and female mice on adult fear conditioning, anxiety-related behavior (elevated plus maze), and addiction-related phenotypes including nicotine sensitivity (hypothermia and locomotor depression) and alcohol sensitivity (loss of righting reflex; LORR). Both shared and strain-specific long-term consequences of adolescent alcohol exposure were found. Most notably, we found a strain-specific alcohol-induced increase in sensitivity to nicotine's hypothermic effects during adulthood in the DBA/2J strain but not in the C57BL/6J strain. Conversely, both strains demonstrated a robust increased latency to LORR during adulthood after adolescent alcohol exposure. Thus, we observed strain-dependent cross-sensitization to nicotine and strain-independent tolerance to alcohol due to adolescent alcohol exposure. Several strain and sex differences independent of adolescent alcohol treatment were also observed. These include increased sensitivity to nicotine-induced hypothermia in the C57BL/6J strain relative to the DBA/2J strain, in addition to DBA/2J mice showing more anxiety-like behaviors in the elevated plus maze relative to the C57BL/6J strain. Overall, these results suggest that adolescent alcohol exposure results in altered adult sensitivity to nicotine and alcohol with some phenotypes mediated by genetic background.

Citing Articles

Age is associated with altered locomotor and hypothermic response to acute nicotine.

Novoa C, Garcia-Trevizo P, Gould T Behav Pharmacol. 2024; 36(1):60-69.

PMID: 39660850 PMC: 11836891. DOI: 10.1097/FBP.0000000000000804.

Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models.

Sicher A, Liss A, Vozella V, Marsland P, Seemiller L, Springer M bioRxiv. 2024; .

PMID: 38746266 PMC: 11092607. DOI: 10.1101/2024.04.30.591674.

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