Fas Ligand Intracellular Signaling: Does PSTPIP Mediate T Cell Death?
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Abstract
Fas and Fas ligand (FasL)-induced cell death is critical for the appropriate regulation of immune responses, especially those mediated by T cells. In this letter, several studies are discussed that reinforce the importance of FasL intracellular signaling for CD4 + T cell death, which might involve PSTPIP phosphatase and/or MAPKs.
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Lee H, Chang P, Wo H, Chou S, Chou C Int J Mol Sci. 2025; 26(2).
PMID: 39859328 PMC: 11766167. DOI: 10.3390/ijms26020615.
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