Human Umbilical Cord Mesenchymal Stem Cells in Diabetes Mellitus and Its Complications: Applications and Research Advances

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2023 Oct 4

PMID 37790847

Authors

Luyao Li

Jicui Li

Haifei Guan

Hisashi Oishi

Satoru Takahashi

Chuan Zhang

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus and its complications pose a major threat to global health and affect the quality of life and life expectancy of patients. Currently, the application of traditional therapeutic drugs for diabetes mellitus has great limitations and can only temporarily control blood glucose but not fundamentally cure it. Mesenchymal stem cells, as pluripotent stromal cells, have multidirectional differentiation potential, high self-renewal, immune regulation, and low immunogenicity, which provide a new idea and possible development direction for diabetes mellitus treatment. Regenerative medicine with mesenchymal stem cells treatment as the core treatment will become another treatment option for diabetes mellitus after traditional treatment. Recently, human umbilical cord mesenchymal stem cells have been widely used in basic and clinical research on diabetes mellitus and its complications because of their abundance, low ethical controversy, low risk of infection, and high proliferation and differentiation ability. This paper reviews the therapeutic role and mechanism of human umbilical cord mesenchymal stem cells in diabetes mellitus and its complications and highlights the challenges faced by the clinical application of human umbilical cord mesenchymal stem cells to provide a more theoretical basis for the application of human umbilical cord mesenchymal stem cells in diabetes mellitus patients.

Citing Articles

Postprandial Glucose Response in Type 2 Diabetes Mellitus Patients and Possible Antioxidant Properties of a Plant-Based Snack Bar.

Dimopoulou M, Bargiota A, Barmpa E, Outskouni Z, Stagos D, Trachana V Foods. 2025; 13(24.

PMID: 39767064 PMC: 11675813. DOI: 10.3390/foods13244123.

Human umbilical mesenchymal stem cells ameliorate atrophic gastritis in aging mice by participating in mitochondrial autophagy through Ndufs8 signaling.

Rui Q, Li C, Rui Y, Zhang C, Xia C, Wang Q Stem Cell Res Ther. 2024; 15(1):491.

PMID: 39707499 PMC: 11662822. DOI: 10.1186/s13287-024-04094-4.

Injectable decellularized Wharton's jelly hydrogel containing CD56 umbilical cord mesenchymal stem cell-derived exosomes for meniscus tear healing and cartilage protection.

Kang S, Shi X, Chen Y, Zhang L, Liu Q, Lin Z Mater Today Bio. 2024; 29:101258.

PMID: 39347017 PMC: 11437876. DOI: 10.1016/j.mtbio.2024.101258.

Perspectives on Stem Cell Therapy in Diabetic Neuropathic Pain.

Montagnoli T, Santos A, Sudo S, Gubert F, Vasques J, Mendez-Otero R Neurol Int. 2024; 16(5):933-944.

PMID: 39311343 PMC: 11417725. DOI: 10.3390/neurolint16050070.

References

Seyedi F, Farsinejad A, Moshrefi M, Nematollahi-Mahani S . In vitro evaluation of different protocols for the induction of mesenchymal stem cells to insulin-producing cells. In Vitro Cell Dev Biol Anim. 2015; 51(8):866-78. DOI: 10.1007/s11626-015-9890-2. View

Yin Y, Hao H, Cheng Y, Gao J, Liu J, Xie Z . The homing of human umbilical cord-derived mesenchymal stem cells and the subsequent modulation of macrophage polarization in type 2 diabetic mice. Int Immunopharmacol. 2018; 60:235-245. DOI: 10.1016/j.intimp.2018.04.051. View

Yap S, Tan K, Abd Rahaman N, Hamid N, Ooi D, Tor Y . Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorated Insulin Resistance in Type 2 Diabetes Mellitus Rats. Pharmaceutics. 2022; 14(3). PMC: 8948940. DOI: 10.3390/pharmaceutics14030649. View

Ali M, Pearson-Stuttard J, Selvin E, Gregg E . Interpreting global trends in type 2 diabetes complications and mortality. Diabetologia. 2021; 65(1):3-13. PMC: 8660730. DOI: 10.1007/s00125-021-05585-2. View

Chang J, Hung S, Wu H, Wu W, Yang A, Tsai H . Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis. Cell Transplant. 2010; 20(2):245-57. DOI: 10.3727/096368910X520056. View

Kong D, Zhuang X, Wang D, Qu H, Jiang Y, Li X . Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus. Clin Lab. 2015; 60(12):1969-76. DOI: 10.7754/clin.lab.2014.140305. View

Li J, Xu S, Zhao Y, Yu S, Ge L, Xu B . Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord. Mol Med Rep. 2018; 18(6):4969-4977. PMC: 6236220. DOI: 10.3892/mmr.2018.9501. View

Xue J, Cheng Y, Hao H, Gao J, Yin Y, Yu S . Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice. Stem Cells Int. 2020; 2020:4689798. PMC: 7157805. DOI: 10.1155/2020/4689798. View

Blakytny R, Jude E . The molecular biology of chronic wounds and delayed healing in diabetes. Diabet Med. 2006; 23(6):594-608. DOI: 10.1111/j.1464-5491.2006.01773.x. View

10.

Nilforoushzadeh M, Raoofi A, Afzali H, Gholami O, Zare S, Nasiry D . Promotion of cutaneous diabetic wound healing by subcutaneous administration of Wharton's jelly mesenchymal stem cells derived from umbilical cord. Arch Dermatol Res. 2022; 315(2):147-159. DOI: 10.1007/s00403-022-02326-2. View

11.

Wu D, Zou S, Chen H, Li X, Xu Y, Zuo Q . Transplantation routes affect the efficacy of human umbilical cord mesenchymal stem cells in a rat GDM model. Clin Chim Acta. 2017; 475:137-146. DOI: 10.1016/j.cca.2017.10.013. View

12.

Wang W, Wu R, Chen P, Xu X, Shi X, Huang L . Liraglutide combined with human umbilical cord mesenchymal stem cell transplantation inhibits beta-cell apoptosis via mediating the ASK1/JNK/BAX pathway in rats with type 2 diabetes. Diabetes Metab Res Rev. 2019; 36(2):e3212. DOI: 10.1002/dmrr.3212. View

13.

Santema K, Stoekenbroek R, Koelemay M, Reekers J, van Dortmont L, Oomen A . Hyperbaric Oxygen Therapy in the Treatment of Ischemic Lower- Extremity Ulcers in Patients With Diabetes: Results of the DAMOCLES Multicenter Randomized Clinical Trial. Diabetes Care. 2017; 41(1):112-119. DOI: 10.2337/dc17-0654. View

14.

Han Y, Sun T, Han Y, Lin L, Liu C, Liu J . Human umbilical cord mesenchymal stem cells implantation accelerates cutaneous wound healing in diabetic rats via the Wnt signaling pathway. Eur J Med Res. 2019; 24(1):10. PMC: 6367839. DOI: 10.1186/s40001-019-0366-9. View

15.

Newman M, Davis C, Kuzmin-Nichols N, Sanberg P . Human umbilical cord blood (HUCB) cells for central nervous system repair. Neurotox Res. 2004; 5(5):355-68. DOI: 10.1007/BF03033155. View

16.

He D, Wang J, Gao Y, Zhang Y . Differentiation of PDX1 gene-modified human umbilical cord mesenchymal stem cells into insulin-producing cells in vitro. Int J Mol Med. 2011; 28(6):1019-24. DOI: 10.3892/ijmm.2011.774. View

17.

Roca-Ho H, Riera M, Palau V, Pascual J, Soler M . Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse. Int J Mol Sci. 2017; 18(3). PMC: 5372579. DOI: 10.3390/ijms18030563. View

18.

Milan P, Lotfibakhshaiesh N, Joghataie M, Ai J, Pazouki A, Kaplan D . Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells. Acta Biomater. 2016; 45:234-246. PMC: 5069185. DOI: 10.1016/j.actbio.2016.08.053. View

19.

Lin C, Lee H, Lee S, Lee W, Cho C, Lin S . Role of HIF-1α-activated Epac1 on HSC-mediated neuroplasticity in stroke model. Neurobiol Dis. 2013; 58:76-91. DOI: 10.1016/j.nbd.2013.05.006. View

20.

Xiang E, Han B, Zhang Q, Rao W, Wang Z, Chang C . Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Res Ther. 2020; 11(1):336. PMC: 7397631. DOI: 10.1186/s13287-020-01852-y. View