Endogenous Inhibitory Mechanisms in Asthma

Overview

Journal J Allergy Clin Immunol Glob

Specialty Allergy & Immunology

Date 2023 Oct 2

PMID 37781649

Authors

Sergio E Chiarella

Peter J Barnes

Affiliations

Soon will be listed here.

Abstract

Endogenous inhibitory mechanisms promote resolution of inflammation, enhance tissue repair and integrity, and promote homeostasis in the lung. These mechanisms include steroid hormones, regulatory T cells, IL-10, prostaglandin E, prostaglandin I, lipoxins, resolvins, protectins, maresins, glucagon-like peptide-1 receptor, adrenomedullin, nitric oxide, and carbon monoxide. Here we review the most recent literature regarding these endogenous inhibitory mechanisms in asthma, which remain a promising target for the prevention and treatment of asthma.

Citing Articles

Potential Use of GLP-1 and GIP/GLP-1 Receptor Agonists for Respiratory Disorders: Where Are We at?.

Janic M, Skrgat S, Harlander M, Lunder M, Janez A, Pantea Stoian A Medicina (Kaunas). 2025; 60(12.

PMID: 39768911 PMC: 11728110. DOI: 10.3390/medicina60122030.

Proresolving Lipid Mediators in the Respiratory System.

Serhan C, Levy B Annu Rev Physiol. 2024; 87(1):491-512.

PMID: 39303274 PMC: 11810588. DOI: 10.1146/annurev-physiol-020924-033209.

Innate immune responses are increased in children with acute asthma exacerbation.

Sheikh S, Eisner M, Walum J, Heyob K, Khan A, Lewis B Pediatr Allergy Immunol. 2024; 35(6):e14173.

PMID: 38873916 PMC: 11182652. DOI: 10.1111/pai.14173.

Interleukin-10 multitasking in allergic airway inflammation.

Hendriks R Cell Mol Immunol. 2023; 20(12):1530-1532.

PMID: 37990033 PMC: 10686977. DOI: 10.1038/s41423-023-01101-1.

References

Lim S, Crawley E, Woo P, Barnes P . Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet. 1998; 352(9122):113. DOI: 10.1016/S0140-6736(98)85018-6. View

Wenzel S, Robinson C, Leonard J, Panettieri Jr R . Nebulized dehydroepiandrosterone-3-sulfate improves asthma control in the moderate-to-severe asthma results of a 6-week, randomized, double-blind, placebo-controlled study. Allergy Asthma Proc. 2011; 31(6):461-71. DOI: 10.2500/aap.2010.31.3384. View

Smyth L, Eustace A, Kolsum U, Blaikely J, Singh D . Increased airway T regulatory cells in asthmatic subjects. Chest. 2010; 138(4):905-12. DOI: 10.1378/chest.09-3079. View

Schleimer R . Potential regulation of inflammation in the lung by local metabolism of hydrocortisone. Am J Respir Cell Mol Biol. 1991; 4(2):166-73. DOI: 10.1165/ajrcmb/4.2.166. View

Stalder A, Lott D, Strasser D, Cruz H, Krause A, Groenen P . Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2016; 83(3):476-486. PMC: 5306489. DOI: 10.1111/bcp.13149. View

Branchett W, Stolting H, Oliver R, Walker S, Puttur F, Gregory L . A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma. J Allergy Clin Immunol. 2019; 145(2):666-678.e9. PMC: 7014588. DOI: 10.1016/j.jaci.2019.08.006. View

Flesher R, Herbert C, Kumar R . Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma. Clin Sci (Lond). 2013; 126(11):805-14. DOI: 10.1042/CS20130623. View

Taylor D, McGrath J, ORR L, Barnes P, OConnor B . Effect of endogenous nitric oxide inhibition on airway responsiveness to histamine and adenosine-5'-monophosphate in asthma. Thorax. 1998; 53(6):483-9. PMC: 1745235. DOI: 10.1136/thx.53.6.483. View

Barnes P . Glucocorticosteroids: current and future directions. Br J Pharmacol. 2011; 163(1):29-43. PMC: 3085866. DOI: 10.1111/j.1476-5381.2010.01199.x. View

10.

Kawakami Y, Uchiyama K, Irie T, Murao M . Evaluation of aerosols of prostaglandins E1 and E2 as bronchodilators. Eur J Clin Pharmacol. 1973; 6(2):127-32. DOI: 10.1007/BF00562439. View

11.

Barnes P . NO or no NO in asthma?. Thorax. 1996; 51(2):218-20. PMC: 473053. DOI: 10.1136/thx.51.2.218. View

12.

Thorburn A, Hansbro P . Harnessing regulatory T cells to suppress asthma: from potential to therapy. Am J Respir Cell Mol Biol. 2010; 43(5):511-9. PMC: 2970851. DOI: 10.1165/rcmb.2009-0342TR. View

13.

Almolki A, Taille C, Martin G, Jose P, Zedda C, Conti M . Heme oxygenase attenuates allergen-induced airway inflammation and hyperreactivity in guinea pigs. Am J Physiol Lung Cell Mol Physiol. 2004; 287(1):L26-34. DOI: 10.1152/ajplung.00237.2003. View

14.

Schreiber T, Wolf D, Tsai M, Chirinos J, Deyev V, Gonzalez L . Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J Clin Invest. 2010; 120(10):3629-40. PMC: 2947231. DOI: 10.1172/JCI42933. View

15.

Palomares O, Yaman G, Azkur A, Akkoc T, Akdis M, Akdis C . Role of Treg in immune regulation of allergic diseases. Eur J Immunol. 2010; 40(5):1232-40. DOI: 10.1002/eji.200940045. View

16.

Kazani S, Planaguma A, Ono E, Bonini M, Zahid M, Marigowda G . Exhaled breath condensate eicosanoid levels associate with asthma and its severity. J Allergy Clin Immunol. 2013; 132(3):547-553. PMC: 3759610. DOI: 10.1016/j.jaci.2013.01.058. View

17.

Morgan S, McCabe E, Gathercole L, Hassan-Smith Z, Larner D, Bujalska I . 11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess. Proc Natl Acad Sci U S A. 2014; 111(24):E2482-91. PMC: 4066483. DOI: 10.1073/pnas.1323681111. View

18.

Kharitonov S, Barnes P . Exhaled markers of pulmonary disease. Am J Respir Crit Care Med. 2001; 163(7):1693-722. DOI: 10.1164/ajrccm.163.7.2009041. View

19.

Lv J, Su W, Yu Q, Zhang M, Di C, Lin X . Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma. J Biol Chem. 2018; 293(48):18454-18465. PMC: 6290169. DOI: 10.1074/jbc.RA118.004950. View

20.

Kamoi H, Kanazawa H, Hirata K, Kurihara N, Yano Y, Otani S . Adrenomedullin inhibits the secretion of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, from rat alveolar macrophages. Biochem Biophys Res Commun. 1995; 211(3):1031-5. DOI: 10.1006/bbrc.1995.1914. View