Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2023 Oct 2

PMID 37781521

Authors

Beiying Deng

Kunpeng Wang

Lilong Zhang

Zhendong Qiu

Weiguo Dong

Weixing Wang

Affiliations

Soon will be listed here.

Abstract

Photodynamic therapy (PDT) is a minimally invasive treatment that effectively targets cancer and inflammatory diseases. It has gained recognition for its efficacy, low toxicity, and potential for repeated use. Colorectal cancer (CRC) and inflammatory bowel diseases (IBD), including Crohn's disease (CD), and ulcerative colitis (UC), impose a significant burden on global intestinal health, with increasing incidence and prevalence rates. PDT shows promise as an emerging approach for gastrointestinal disease treatment, particularly IBD and CRC. Extensive preclinical research has demonstrated the safety and effectiveness of PDT for IBD and CRC, while clinical studies are currently underway. This review provides an overview of the underlying mechanisms responsible for the anti-inflammatory and anti-tumor effects of PDT, offering insights into the clinical application of PDT in IBD and CRC treatment. It is expected that this review will serve as a valuable reference for future research on PDT for CRC and IBD, contributing to advancements in the treatment of inflammatory and cancerous diseases of the intestines.

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References

Shui S, Zhao Z, Wang H, Conrad M, Liu G . Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway. Redox Biol. 2021; 45:102056. PMC: 8264218. DOI: 10.1016/j.redox.2021.102056. View

Shin Y, Park Y, Lee H, Choi Y, Eom J . Real-Time Monitoring of Colorectal Cancer Location and Lymph Node Metastasis and Photodynamic Therapy Using Fucoidan-Based Therapeutic Nanogel and Near-Infrared Fluorescence Diagnostic-Therapy System. Pharmaceutics. 2023; 15(3). PMC: 10057966. DOI: 10.3390/pharmaceutics15030930. View

Kleban J, Mikes J, Szilardiova B, Koval J, Sackova V, Solar P . Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells. Photochem Photobiol. 2007; 83(5):1174-85. DOI: 10.1111/j.1751-1097.2007.00127.x. View

Zhou H, Liu Z, Wang Y, Wen X, Amador E, Yuan L . Colorectal liver metastasis: molecular mechanism and interventional therapy. Signal Transduct Target Ther. 2022; 7(1):70. PMC: 8897452. DOI: 10.1038/s41392-022-00922-2. View

He S, Li J, Cheng P, Zeng Z, Zhang C, Duan H . Charge-Reversal Polymer Nano-modulators for Photodynamic Immunotherapy of Cancer. Angew Chem Int Ed Engl. 2021; 60(35):19355-19363. DOI: 10.1002/anie.202106392. View

Klinger A, Kann B . Endoscopy in Inflammatory Bowel Disease. Surg Clin North Am. 2019; 99(6):1063-1082. DOI: 10.1016/j.suc.2019.08.005. View

Allardice J, Abulafi A, Grahn M, Williams N . Adjuvant intraoperative photodynamic therapy for colorectal carcinoma: a clinical study. Surg Oncol. 1994; 3(1):1-10. DOI: 10.1016/0960-7404(94)90018-3. View

Frigerio S, Lartey D, DHaens G, Grootjans J . The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms. Int J Mol Sci. 2021; 22(23). PMC: 8657929. DOI: 10.3390/ijms222312739. View

Chen J, Fan T, Xie Z, Zeng Q, Xue P, Zheng T . Advances in nanomaterials for photodynamic therapy applications: Status and challenges. Biomaterials. 2020; 237:119827. DOI: 10.1016/j.biomaterials.2020.119827. View

10.

van Duijnhoven F, Rovers J, Engelmann K, Krajina Z, Purkiss S, Zoetmulder F . Photodynamic therapy with 5,10,15,20-tetrakis(m-hydroxyphenyl) bacteriochlorin for colorectal liver metastases is safe and feasible: results from a phase I study. Ann Surg Oncol. 2005; 12(10):808-16. DOI: 10.1245/ASO.2005.09.005. View

11.

Rodriguez M, Catrinacio C, Ropolo A, Rivarola V, Vaccaro M . A novel HIF-1α/VMP1-autophagic pathway induces resistance to photodynamic therapy in colon cancer cells. Photochem Photobiol Sci. 2017; 16(11):1631-1642. DOI: 10.1039/c7pp00161d. View

12.

Apte R, Chen D, Ferrara N . VEGF in Signaling and Disease: Beyond Discovery and Development. Cell. 2019; 176(6):1248-1264. PMC: 6410740. DOI: 10.1016/j.cell.2019.01.021. View

13.

Li H, Zhang Z, Zhang H, Guo Y, Yao Z . Update on the Pathogenesis and Therapy of Atopic Dermatitis. Clin Rev Allergy Immunol. 2021; 61(3):324-338. DOI: 10.1007/s12016-021-08880-3. View

14.

Levine B, Kroemer G . Biological Functions of Autophagy Genes: A Disease Perspective. Cell. 2019; 176(1-2):11-42. PMC: 6347410. DOI: 10.1016/j.cell.2018.09.048. View

15.

Liu K, Lei S, Kuang Y, Jin Q, Long D, Liu C . A Novel Mechanism of the c-Myc/NEAT1 Axis Mediating Colorectal Cancer Cell Response to Photodynamic Therapy Treatment. Front Oncol. 2021; 11:652831. PMC: 8355738. DOI: 10.3389/fonc.2021.652831. View

16.

Turubanova V, Balalaeva I, Mishchenko T, Catanzaro E, Alzeibak R, Peskova N . Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine. J Immunother Cancer. 2019; 7(1):350. PMC: 6916435. DOI: 10.1186/s40425-019-0826-3. View

17.

Xu M, Zhou L, Zheng L, Zhou Q, Liu K, Mao Y . Sonodynamic therapy-derived multimodal synergistic cancer therapy. Cancer Lett. 2020; 497:229-242. DOI: 10.1016/j.canlet.2020.10.037. View

18.

Sardoiwala M, Kushwaha A, Dev A, Shrimali N, Guchhait P, Karmakar S . Hypericin-Loaded Transferrin Nanoparticles Induce PP2A-Regulated BMI1 Degradation in Colorectal Cancer-Specific Chemo-Photodynamic Therapy. ACS Biomater Sci Eng. 2021; 6(5):3139-3153. DOI: 10.1021/acsbiomaterials.9b01844. View

19.

Papamichael K, Stocco G, Ruiz Del Agua A . Challenges in Therapeutic Drug Monitoring: Optimizing Biological Treatments in Patients With Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases. Ther Drug Monit. 2023; 45(5):579-590. PMC: 10497208. DOI: 10.1097/FTD.0000000000001095. View

20.

Favre L, Borle F, Velin D, Bachmann D, Bouzourene H, Wagnieres G . Low dose endoluminal photodynamic therapy improves murine T cell-mediated colitis. Endoscopy. 2011; 43(7):604-16. DOI: 10.1055/s-0030-1256382. View