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P53 and MYC-regulated Squalene Epoxidase As Achilles Heel in Colorectal Cancer

Overview
Journal Int J Biol Sci
Specialty Biology
Date 2023 Oct 2
PMID 37781510
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Abstract

The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells. The p53 and MYC-regulated squalene epoxidase (SQLE) has been identified as a potential Achilles heel in colorectal cancer. This is of great interest because the FDA-approved anti-fungal SQLE inhibitor Terbinafine could be repurposed to treat colorectal cancer patients.

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