SEMA4A Promotes Prostate Cancer Invasion: Involvement of Tumor Microenvironment

Overview

Journal J Cancer

Specialty Oncology

Date 2023 Oct 2

PMID 37779872

Authors

Xiao Liu

Weiwei Tan

Weiqi Wang

Tingting Feng

Chunni Wang

Lin Wang

Wei Zhou

Affiliations

Soon will be listed here.

Abstract

Semaphorin 4A (SEMA4A) belonged to a family of membrane-bound proteins that were initially recognized as a kind of axon guidance factors in nervous system. It was preferentially expressed on immune cells and has been proven to play a prominent role in immune function and angiogenesis. In this study, we found that SEMA4A was highly expressed in prostate cancer (PCa) tissues and correlated with Gleason scores and distant metastasis. SEMA4A could induce Epithelial-mesenchymal transition (EMT) of PCa cells and consequently promote invasion by establishing a positive loop with IL-10 in stromal cells. experiments showed more dissemination in mice injected with SEMA4A-overexpressing cells in mouse models and both the number and size of lung metastases were significantly increased in SEMA4A-overexpressing tumors. SEMA4A depletion by genetic means prevents lung metastasis in PCa xenograft models. Our data suggest a crucial role of SEMA4A in PCa and blocking SEMA4A-IL-10 axis represents an attractive approach to improving therapeutic outcomes.

Citing Articles

A Pilot Study of the Role of Semaphorin 4A (sema4A) and 3C (sema3C) in Non-Muscle-Invasive Bladder Cancer (NMIBC).

Purpurowicz P, Kaminski T, Kordan W, Korzekwa A, Purpurowicz Z, Jablonowski Z Biomedicines. 2024; 12(10).

PMID: 39457718 PMC: 11504222. DOI: 10.3390/biomedicines12102407.

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