The Smell of Death. State-of-the-art and Future Research Directions

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2023 Oct 2

PMID 37779703

Authors

Julia Ciesla

Julia Skrobisz

Bartosz Nicinski

Magdalena Kloc

Katarzyna Mazur

Artur Palasz

Gulnaz T Javan

Marcin Tomsia

Affiliations

Soon will be listed here.

Abstract

The decomposition of a body is inseparably associated with the release of several types of odors. This phenomenon has been used in the training of sniffer dogs for decades. The odor profile associated with decomposition consists of a range of volatile organic compounds (VOCs), chemical composition of which varies over time, temperature, environmental conditions, and the type of microorganisms, and insects colonizing the carcass. Mercaptans are responsible for the bad smell associated with corpses; however, there are no unified recommendations for conducting forensic analysis based on the detectable odor of revealed corpses and previous research on VOCs shows differing results. The aim of this review is to systematize the current knowledge on the type of volatile organic compounds related to the decomposition process, depending on a few variables. This knowledge will improve the methods of VOCs detection and analysis to be used in modern forensic diagnostics and improve the methods of training dogs for forensic applications.

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References

De-Giorgio F, Nardini M, Foti F, Minelli E, Papi M, dAloja E . A novel method for post-mortem interval estimation based on tissue nano-mechanics. Int J Legal Med. 2019; 133(4):1133-1139. DOI: 10.1007/s00414-019-02034-z. View

Stefanuto P, Perrault K, Stadler S, Pesesse R, LeBlanc H, Forbes S . GC × GC-TOFMS and supervised multivariate approaches to study human cadaveric decomposition olfactive signatures. Anal Bioanal Chem. 2015; 407(16):4767-78. DOI: 10.1007/s00216-015-8683-5. View

Vickers N . Mechanisms of animal navigation in odor plumes. Biol Bull. 2000; 198(2):203-12. DOI: 10.2307/1542524. View

Brodie B, Babcock T, Gries R, Benn A, Gries G . Acquired Smell? Mature Females of the Common Green Bottle Fly Shift Semiochemical Preferences from Feces Feeding Sites to Carrion Oviposition Sites. J Chem Ecol. 2015; 42(1):40-50. DOI: 10.1007/s10886-015-0658-7. View

Martin C, Minchilli D, Francis F, Verheggen F . Behavioral and Electrophysiological Responses of the Fringed Larder Beetle to the Smell of a Cadaver at Different Decomposition Stages. Insects. 2020; 11(4). PMC: 7240428. DOI: 10.3390/insects11040238. View

Pascual J, von Hoermann C, Rottler-Hoermann A, Nevo O, Geppert A, Sikorski J . Function of bacterial community dynamics in the formation of cadaveric semiochemicals during in situ carcass decomposition. Environ Microbiol. 2017; 19(8):3310-3322. DOI: 10.1111/1462-2920.13828. View

Megyesi M, Nawrocki S, Haskell N . Using accumulated degree-days to estimate the postmortem interval from decomposed human remains. J Forensic Sci. 2005; 50(3):618-26. View

Miles K, Finaughty D, Gibbon V . A review of experimental design in forensic taphonomy: moving towards forensic realism. Forensic Sci Res. 2021; 5(4):249-259. PMC: 7782990. DOI: 10.1080/20961790.2020.1792631. View

Statheropoulos M, Spiliopoulou C, Agapiou A . A study of volatile organic compounds evolved from the decaying human body. Forensic Sci Int. 2005; 153(2-3):147-55. DOI: 10.1016/j.forsciint.2004.08.015. View

10.

Delclos P, Bouldin T, Tomberlin J . Olfactory Choice for Decomposition Stage in the Burying Beetle : Preference or Aversion?. Insects. 2020; 12(1). PMC: 7824017. DOI: 10.3390/insects12010011. View

11.

Gill J, Marker E, Stajic M . Suicide by cyanide: 17 deaths. J Forensic Sci. 2004; 49(4):826-8. View

12.

Javan G, Finley S, Tuomisto S, Hall A, Benbow M, Mills D . An interdisciplinary review of the thanatomicrobiome in human decomposition. Forensic Sci Med Pathol. 2018; 15(1):75-83. DOI: 10.1007/s12024-018-0061-0. View

13.

Baryah N, Krishan K, Kanchan T . The development and status of forensic anthropology in India: A review of the literature and future directions. Med Sci Law. 2019; 59(1):61-69. DOI: 10.1177/0025802418824834. View

14.

Moraleda V, Gomez-Catasus J, Schuster C, Carrascal L . Decomposition stages as a clue for estimating the post-mortem interval in carcasses and providing accurate bird collision rates. Sci Rep. 2022; 12(1):16188. PMC: 9519910. DOI: 10.1038/s41598-022-20628-3. View

15.

Turner B, Wiltshire P . Experimental validation of forensic evidence: a study of the decomposition of buried pigs in a heavy clay soil. Forensic Sci Int. 1999; 101(2):113-22. DOI: 10.1016/s0379-0738(99)00018-3. View

16.

Matuszewski S, Hall M, Moreau G, Schoenly K, Tarone A, Villet M . Pigs vs people: the use of pigs as analogues for humans in forensic entomology and taphonomy research. Int J Legal Med. 2019; 134(2):793-810. PMC: 7044136. DOI: 10.1007/s00414-019-02074-5. View

17.

Connor M, Baigent C, Hansen E . Testing the Use of Pigs as Human Proxies in Decomposition Studies. J Forensic Sci. 2017; 63(5):1350-1355. DOI: 10.1111/1556-4029.13727. View

18.

Statheropoulos M, Agapiou A, Spiliopoulou C, Pallis G, Sianos E . Environmental aspects of VOCs evolved in the early stages of human decomposition. Sci Total Environ. 2007; 385(1-3):221-7. DOI: 10.1016/j.scitotenv.2007.07.003. View

19.

Matuszewski S . Post-Mortem Interval Estimation Based on Insect Evidence: Current Challenges. Insects. 2021; 12(4). PMC: 8066566. DOI: 10.3390/insects12040314. View

20.

Frederickx C, Dekeirsschieter J, Verheggen F, Haubruge E . Responses of Lucilia sericata Meigen (Diptera: Calliphoridae) to cadaveric volatile organic compounds. J Forensic Sci. 2011; 57(2):386-90. DOI: 10.1111/j.1556-4029.2011.02010.x. View