Prospective Longitudinal Associations Between Adverse Childhood Experiences and Adult Mental Health Outcomes: a Protocol for a Systematic Review and Meta-analysis

Overview

Journal Syst Rev

Publisher Biomed Central

Date 2023 Sep 30

PMID 37777785

Authors

Christina Thurston

Aja Louise Murray

Hannabeth Franchino-Olsen

Franziska Meinck

Affiliations

Soon will be listed here.

Abstract

Background: Research cites a strong, dose-response relationship between adverse childhood experiences (ACEs) and poor adult mental health outcomes including anxiety, depression, post-traumatic stress disorder (PTSD), self-harm, suicidality, and psychotic-like experiences.

Aim: To systematically investigate the existence and strength of association between ACEs and adult mental health outcomes in prospective longitudinal studies. The review will focus on the outcomes: anxiety, depression, PTSD, self-harm, suicidal ideation, and psychotic-like experiences.

Methods: Twelve electronic databases will be searched: Embase, PsycINFO, MEDLINE, and Global Health through the OVID interface. ProQuest will be used to search Public Affairs Information Service (PAIS), Dissertations and Theses, Sociology Database (including Sociological Abstracts and Social Services Abstracts), PTSDpubs (formerly The Published International Literature on Traumatic Stress (PILOTS) Database) and Applied Social Sciences Index and Abstracts (ASSIA). CINAHL, World Health Organisation (WHO) Global Index Medicus, and WHO Violence Info will also be searched. Eligible studies will be double screened, assessed, and their data will be extracted. Any disagreement throughout these processes will be settled by a third reviewer. If enough studies meet the criteria and the methodological quality of each study is sufficient, a meta-analysis will be conducted.

Analysis: A narrative synthesis of included studies and the associations between ACEs and adult mental health will be completed. If the number of studies included per mental health outcome is two or more, a multi-level meta-analysis will be completed using odds ratio effect sizes as outcomes.

Discussion: This review will contribute to the existing body of literature supporting the long-term effects of ACEs on adult mental health. This review adds to previous reviews that have either synthesised cross-sectional associations between ACEs and mental health outcomes, synthesised longitudinal studies exploring the effect of ACEs on different physical and mental health outcomes or synthesised longitudinal studies exploring the effect of ACEs on the same mental health outcomes using different methods. This review aims to identify methodological weaknesses and knowledge gaps in current literature that can be addressed in future primary studies.

Systematic Review Registration: This protocol has been registered in PROSPERO (CRD42021297882).

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References

Goncalves H, Soares A, Gomes Dos Santos A, Ribeiro C, Bierhals I, Vieira L . Adverse childhood experiences and consumption of alcohol, tobacco and illicit drugs among adolescents of a Brazilian birth cohort. Cad Saude Publica. 2016; 32(10):e00085815. DOI: 10.1590/0102-311X00085815. View

Dube S, Williamson D, Thompson T, Felitti V, Anda R . Assessing the reliability of retrospective reports of adverse childhood experiences among adult HMO members attending a primary care clinic. Child Abuse Negl. 2004; 28(7):729-37. DOI: 10.1016/j.chiabu.2003.08.009. View

Duval S, Tweedie R . Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000; 56(2):455-63. DOI: 10.1111/j.0006-341x.2000.00455.x. View

Baldwin J, Reuben A, Newbury J, Danese A . Agreement Between Prospective and Retrospective Measures of Childhood Maltreatment: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2019; 76(6):584-593. PMC: 6551848. DOI: 10.1001/jamapsychiatry.2019.0097. View

Walter S . Choice of effect measure for epidemiological data. J Clin Epidemiol. 2000; 53(9):931-9. DOI: 10.1016/s0895-4356(00)00210-9. View

Hasselblad V, Hedges L . Meta-analysis of screening and diagnostic tests. Psychol Bull. 1995; 117(1):167-78. DOI: 10.1037/0033-2909.117.1.167. View

VanderWeele T . Principles of confounder selection. Eur J Epidemiol. 2019; 34(3):211-219. PMC: 6447501. DOI: 10.1007/s10654-019-00494-6. View

Auersperg F, Vlasak T, Ponocny I, Barth A . Long-term effects of parental divorce on mental health - A meta-analysis. J Psychiatr Res. 2019; 119:107-115. DOI: 10.1016/j.jpsychires.2019.09.011. View

YARROW M, Campbell J, BURTON R . Recollections of childhood. A study of the retrospective method. Monogr Soc Res Child Dev. 1970; 35(5):1-83. View

10.

Kalmakis K, Chandler G . Health consequences of adverse childhood experiences: a systematic review. J Am Assoc Nurse Pract. 2015; 27(8):457-65. DOI: 10.1002/2327-6924.12215. View

11.

El Mhamdi S, Lemieux A, Bouanene I, Ben Salah A, Nakajima M, Ben Salem K . Gender differences in adverse childhood experiences, collective violence, and the risk for addictive behaviors among university students in Tunisia. Prev Med. 2017; 99:99-104. DOI: 10.1016/j.ypmed.2017.02.011. View

12.

Cluver L, Orkin M, Boyes M, Sherr L . Child and Adolescent Suicide Attempts, Suicidal Behavior, and Adverse Childhood Experiences in South Africa: A Prospective Study. J Adolesc Health. 2015; 57(1):52-9. DOI: 10.1016/j.jadohealth.2015.03.001. View

13.

Nadan Y, Spilsbury J, Korbin J . Culture and context in understanding child maltreatment: Contributions of intersectionality and neighborhood-based research. Child Abuse Negl. 2014; 41:40-8. DOI: 10.1016/j.chiabu.2014.10.021. View

14.

Kisely S, Abajobir A, Mills R, Strathearn L, Clavarino A, Najman J . Child maltreatment and mental health problems in adulthood: birth cohort study. Br J Psychiatry. 2018; 213(6):698-703. DOI: 10.1192/bjp.2018.207. View

15.

Widom C, DuMont K, Czaja S . A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Arch Gen Psychiatry. 2007; 64(1):49-56. DOI: 10.1001/archpsyc.64.1.49. View

16.

Van Dam D, van der Ven E, Velthorst E, Selten J, Morgan C, de Haan L . Childhood bullying and the association with psychosis in non-clinical and clinical samples: a review and meta-analysis. Psychol Med. 2012; 42(12):2463-74. DOI: 10.1017/S0033291712000360. View

17.

Paez A . Gray literature: An important resource in systematic reviews. J Evid Based Med. 2017; 10(3):233-240. DOI: 10.1111/jebm.12266. View

18.

van Lent M, Overbeke J, Out H . Role of editorial and peer review processes in publication bias: analysis of drug trials submitted to eight medical journals. PLoS One. 2014; 9(8):e104846. PMC: 4130599. DOI: 10.1371/journal.pone.0104846. View

19.

Merrick M, Ports K, Ford D, Afifi T, Gershoff E, Grogan-Kaylor A . Unpacking the impact of adverse childhood experiences on adult mental health. Child Abuse Negl. 2017; 69:10-19. PMC: 6007802. DOI: 10.1016/j.chiabu.2017.03.016. View

20.

Stang A . Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010; 25(9):603-5. DOI: 10.1007/s10654-010-9491-z. View