Variations in Blood Copper and Possible Mechanisms During Pregnancy

Overview

Journal Biol Trace Elem Res

Date 2023 Sep 30

PMID 37777692

Authors

Lihua Guan

Yifei Wang

Liling Lin

Yutong Zou

Ling Qiu

Affiliations

Soon will be listed here.

Abstract

Copper (Cu), an essential trace element, is crucial for both the mother and fetus. Currently, an increasing number of studies have focused on blood copper levels during pregnancy. Studies have found that blood copper levels in pregnant women are higher than those in reproductive-age women, but the trend, mainly in the 2nd and 3rd trimester, is still controversial. Most studies showed that blood copper levels gradually increased during pregnancy, while some studies found that blood copper levels remained stable or even decreased in the 3rd trimester. The possible mechanisms of variations in blood copper during pregnancy include the influence of estrogen (hepatic uptake and excretion, ceruloplasmin synthesis, maternal-fetal transport, etc.), the interaction of other trace elements (Fe, Zn, etc.) and other factors. Among them, maternal-fetal copper transport caused by elevated estrogen may be the main reason for the inconsistencies observed in the 2nd and 3rd trimester during pregnancy. However, there are some mechanisms require further investigation. In the future, the trend and mechanisms of blood copper during pregnancy should be explored more deeply to help doctors better monitor copper status and detect copper abnormalities in time.

Citing Articles

Correlation of Zinc and Copper Levels In Mothers and Cord Blood of Neonates With Prematurity and Intrauterine Growth Pattern.

Garlapati S, Venigalla N, Mane S, Dharmagadda A, Sravanthi K, Gupta A Cureus. 2024; 16(7):e63674.

PMID: 39092406 PMC: 11293485. DOI: 10.7759/cureus.63674.

Establishment of discrete reference interval and next-generation reference interval for copper and zinc during pregnancy using real-world data.

Guan L, Ma C, Lin L, Qiu L Heliyon. 2024; 10(13):e33856.

PMID: 39050426 PMC: 11268205. DOI: 10.1016/j.heliyon.2024.e33856.

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