MicroRNAs and Colorectal Cancer: Clinical Potential and Regulatory Networks

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2023 Sep 30

PMID 37776413

Authors

George Yiadom Osei

Joseph Adu-Amankwaah

Selina Koomson

Solomon Beletaa

Emmanuel Akomanin Asiamah

Cecilia Smith-Togobo

Siti Razila Abdul Razak

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) is a serious global health concern, with a high incidence and mortality rate. Although there have been advancements in the early detection and treatment of CRC, therapy resistance is common. MicroRNAs (miRNAs), a type of small non-coding RNA that regulates gene expression, are key players in the initiation and progression of CRC. Recently, there has been growing attention to the complex interplay of miRNAs in cancer development. miRNAs are powerful RNA molecules that regulate gene expression and have been implicated in various physiological and pathological processes, including carcinogenesis. By identifying current challenges and limitations of treatment strategies and suggesting future research directions, this review aims to contribute to ongoing efforts to enhance CRC diagnosis and treatment. It also provides a comprehensive overview of the role miRNAs play in CRC carcinogenesis and explores the potential of miRNA-based therapies as a treatment option. Importantly, this review highlights the exciting potential of targeted modulation of miRNA function as a therapeutic approach for CRC.

Citing Articles

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