UDP-glucose Dehydrogenase (UGDH) in Clinical Oncology and Cancer Biology

Overview

Journal Oncotarget

Specialty Oncology

Date 2023 Sep 28

PMID 37769033

Authors

Meghan J Price

Annee D Nguyen

Jovita K Byemerwa

Jasmine Flowers

Cesar D Baeta

C Rory Goodwin

Affiliations

Soon will be listed here.

Abstract

UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, we classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describe its involvement in key canonical cancer signaling pathways, and identify methods to inhibit UGDH, its substrates, and its downstream products. As such, we position UGDH as an enzyme to be exploited as a potential prognostication marker in oncology and a therapeutic target in cancer biology.

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