The VBNC State: a Fundamental Survival Strategy of

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2023 Sep 28

PMID 37768061

Authors

Patricia Konig

Alexander Wilhelm

Christoph Schaudinn

Anja Poehlein

Rolf Daniel

Marek Widera

Beate Averhoff

Volker Muller

Affiliations

Soon will be listed here.

Abstract

Currently, the viable but non-culturable (VBNC) state is an underappreciated niche for pathogenic bacteria which provides a continuous source for recurrent infections and transmission. We propose the VBNC state to be a global persistence mechanism used by various strains to cope with many stresses it is confronted with in the clinical environment and in the host. This requires a novel strategy to detect viable cells of this pathogen that is not only based on plating assays.

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