Carambolaside W Inhibited H1N1 Influenza Virus-Induced Oxidative Stress Through STAT-3/BCL-XL Signaling Pathway

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 Sep 28

PMID 37766266

Authors

Jingyao Su

Jia Lai

Jiali Li

Xia Liu

Haitian Chen

Chuqing Li

Bing Zhu

Xuchao Jia

YingHua Li

Affiliations

Soon will be listed here.

Abstract

The H1N1 influenza virus is highly infectious and pathogenic, and in recent years, it has often presented seasonal mass outbreaks of infection. People infected with H1N1 will develop a high fever and other respiratory infection symptoms. If not treated in time, complications such as pneumonia may occur. In this study, we focused on developing drugs that can effectively fight against with H1N1 virus. A flavonoid glycoside was extracted from the carambola, then characterized by HR-ESI-MS with the molecular formula CHO, and named carambolaside W. The flavonoid glycosides were found to have good anti-H1N1 influenza virus effects. In this study, we verified that carambolaside W has low toxicity and can effectively inhibit influenza virus replication . H1N1 virus infection induces intracellular oxidative stress damage to accelerate disease progression. The results showed that carambolaside W effectively inhibited the oxidative stress caused by H1N1 infection. The Western blot assay also revealed that carambolaside W alters the expression of apoptosis-related proteins and exerts a good anti-H1N1 influenza virus effect. In summary, carambolaside W is a low-toxicity natural flavonoid that can effectively treat the H1N1 influenza virus as a potential anti-H1N1 virus agent.

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