β-Cyclodextrin Modified Hydrogels of Kappa-Carrageenan for Methotrexate Delivery

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 Sep 28

PMID 37765213

Authors

Maria Nikitina

Nataliya Kochkina

Marianna Arinina

Valery Kulichikhin

Irina Terekhova

Affiliations

Soon will be listed here.

Abstract

This work is aimed at developing a kappa-carrageenan (kCR) gel with increased methotrexate (MTX) content. β-Cyclodextrin (βCD), which is able to inclusion complex formation with MTX, has been used to increase the drug concentration in the hydrogel. The rheological behavior of the designed gels was investigated and the influence of MTX and βCD on the viscoelastic properties of kCR gel was studied in detail. The effect of βCD and its concentration on the MTX-releasing rate from the kCR gels was examined. The properties of kappa- and iota-carrageenans loaded with MTX were compared and the differences observed were explained in terms of different binding affinities of MTX to these polymers. The obtained gels provided desirable viscoelastic properties useful for topical application.

Citing Articles

Natural Regenerative Hydrogels for Wound Healing.

Chelu M, Calderon Moreno J, Musuc A, Popa M Gels. 2024; 10(9).

PMID: 39330149 PMC: 11431064. DOI: 10.3390/gels10090547.

Cyclodextrin-grafted redox-responsive hydrogel mediated by disulfide bridges for regulated drug delivery.

Xu X, Xu J, Sun Z, Tetiana D Des Monomers Polym. 2024; 27(1):21-34.

PMID: 38826495 PMC: 11141310. DOI: 10.1080/15685551.2024.2358581.

Kappa-carrageenan and sodium alginate-based pH-responsive hydrogels for controlled release of methotrexate.

Qureshi M, Arshad N, Rasool A, Janjua N, Shoaib Butt M, Naqeeb Ur Rehman Qureshi M R Soc Open Sci. 2024; 11(4):231952.

PMID: 38660601 PMC: 11040253. DOI: 10.1098/rsos.231952.

References

Shatwell K . Polysaccharide strong and weak gels. Biorheology. 1993; 30(3-4):217-27. DOI: 10.3233/bir-1993-303-407. View

Miyazaki S, Ishitani M, Takahashi A, Shimoyama T, Itoh K, Attwood D . Carrageenan gels for oral sustained delivery of acetaminophen to dysphagic patients. Biol Pharm Bull. 2011; 34(1):164-6. DOI: 10.1248/bpb.34.164. View

Peppas N, Bures P, Leobandung W, Ichikawa H . Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000; 50(1):27-46. DOI: 10.1016/s0939-6411(00)00090-4. View

Khan M, Ravi P, Mir S, Rawat P . Optimization and in vivo evaluation of triamcinolone acetonide loaded in situ gel prepared using reacted tamarind seed xyloglucan and kappa-carrageenan for ocular delivery. Int J Biol Macromol. 2023; 233:123533. DOI: 10.1016/j.ijbiomac.2023.123533. View

Laurie C, El-Zein M, Botting-Provost S, Tota J, Tellier P, Coutlee F . Efficacy and safety of a self-applied carrageenan-based gel to prevent human papillomavirus infection in sexually active young women (CATCH study): an exploratory phase IIB randomised, placebo-controlled trial. EClinicalMedicine. 2023; 60:102038. PMC: 10314142. DOI: 10.1016/j.eclinm.2023.102038. View

Tripathi P, Kumar A, Jain P, Patel J . Carbomer gel bearing methotrexate loaded lipid nanocontainers shows improved topical delivery intended for effective management of psoriasis. Int J Biol Macromol. 2018; 120(Pt A):1322-1334. DOI: 10.1016/j.ijbiomac.2018.08.136. View

Yuan C, Du L, Zhang G, Jin Z, Liu H . Influence of cyclodextrins on texture behavior and freeze-thaw stability of kappa-carrageenan gel. Food Chem. 2016; 210:600-5. DOI: 10.1016/j.foodchem.2016.05.014. View

Bahramizadeh M, Bahramizadeh M, Kiafar B, Jafarian A, Nikpoor A, Hatamipour M . Development, characterization and evaluation of topical methotrexate-entrapped deformable liposome on imiquimod-induced psoriasis in a mouse model. Int J Pharm. 2019; 569:118623. DOI: 10.1016/j.ijpharm.2019.118623. View

Klitgaard M, Mullertz A, Berthelsen R . Estimating the Oral Absorption from Self-Nanoemulsifying Drug Delivery Systems Using an In Vitro Lipolysis-Permeation Method. Pharmaceutics. 2021; 13(4). PMC: 8065752. DOI: 10.3390/pharmaceutics13040489. View

10.

Xu H, Liu Y, Jin L, Chen X, Chen X, Wang Q . Preparation and Characterization of Ion-Sensitive Brimonidine Tartrate In Situ Gel for Ocular Delivery. Pharmaceuticals (Basel). 2023; 16(1). PMC: 9866900. DOI: 10.3390/ph16010090. View

11.

Chadha R, Arora P, Kaur R, Saini A, Singla M, Jain D . Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques. Acta Pharm. 2009; 59(3):245-57. DOI: 10.2478/v10007-009-0024-9. View

12.

Um I, Ki C, Kweon H, Lee K, Ihm D, Park Y . Wet spinning of silk polymer. II. Effect of drawing on the structural characteristics and properties of filament. Int J Biol Macromol. 2004; 34(1-2):107-19. DOI: 10.1016/j.ijbiomac.2004.03.011. View

13.

Neupane R, Boddu S, Renukuntla J, Jayachandra Babu R, Tiwari A . Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities. Pharmaceutics. 2020; 12(2). PMC: 7076422. DOI: 10.3390/pharmaceutics12020152. View

14.

Sonawane R, Patil S . Fabrication and statistical optimization of starch-κ-carrageenan cross-linked hydrogel composite for extended release pellets of zaltoprofen. Int J Biol Macromol. 2018; 120(Pt B):2324-2334. DOI: 10.1016/j.ijbiomac.2018.08.177. View

15.

Liu J, Zhan X, Wan J, Wang Y, Wang C . Review for carrageenan-based pharmaceutical biomaterials: favourable physical features versus adverse biological effects. Carbohydr Polym. 2015; 121:27-36. DOI: 10.1016/j.carbpol.2014.11.063. View

16.

Yousefi G, Foroutan S, Zarghi A, Shafaati A . Synthesis and characterization of methotrexate polyethylene glycol esters as a drug delivery system. Chem Pharm Bull (Tokyo). 2010; 58(2):147-53. DOI: 10.1248/cpb.58.147. View

17.

Giri B, Yang H, Song I, Choi H, Cho J, Kim D . Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability, Photostability, and Permeability. Pharmaceutics. 2022; 14(10). PMC: 9609692. DOI: 10.3390/pharmaceutics14102073. View

18.

Rasool A, Ata S, Islam A, Rizwan M, Azeem M, Mehmood A . Kinetics and controlled release of lidocaine from novel carrageenan and alginate-based blend hydrogels. Int J Biol Macromol. 2020; 147:67-78. DOI: 10.1016/j.ijbiomac.2020.01.073. View

19.

Yermak I, Gorbach V, Karnakov I, Davydova V, Pimenova E, Chistyulin D . Carrageenan gel beads for echinochrome inclusion: Influence of structural features of carrageenan. Carbohydr Polym. 2021; 272:118479. DOI: 10.1016/j.carbpol.2021.118479. View

20.

Jaiswal L, Shankar S, Rhim J . Carrageenan-based functional hydrogel film reinforced with sulfur nanoparticles and grapefruit seed extract for wound healing application. Carbohydr Polym. 2019; 224:115191. DOI: 10.1016/j.carbpol.2019.115191. View