Editorial for "The Role of Ketogenic Diet in Human Health and Diseases": The Multifaceted Impact of Ketogenic Diets on Health and Disease

Overview

Journal Nutrients

Date 2023 Sep 28

PMID 37764810

Authors

Mikiko Watanabe

Silvia Savastano

Carla Lubrano

Giovanni Spera

Affiliations

Soon will be listed here.

Abstract

The ketogenic diet (KD), characterized by a very low carbohydrate intake and variable protein, fat and calorie intake, has long been in the spotlight for its potential therapeutic applications [...].

References

Condorelli R, Aversa A, Basile L, Cannarella R, Mongioi L, Cimino L . Beneficial Effects of the Very-Low-Calorie Ketogenic Diet on the Symptoms of Male Accessory Gland Inflammation. Nutrients. 2022; 14(5). PMC: 8912840. DOI: 10.3390/nu14051081. View

Battezzati A, Foppiani A, Leone A, De Amicis R, Spadafranca A, Mari A . Acute Insulin Secretory Effects of a Classic Ketogenic Meal in Healthy Subjects: A Randomized Cross-Over Study. Nutrients. 2023; 15(5). PMC: 10005334. DOI: 10.3390/nu15051119. View

Dal Bello S, Valdemarin F, Martinuzzi D, Filippi F, Gigli G, Valente M . Ketogenic Diet in the Treatment of Gliomas and Glioblastomas. Nutrients. 2022; 14(18). PMC: 9504425. DOI: 10.3390/nu14183851. View

Ivan C, Messina A, Cibelli G, Messina G, Polito R, Losavio F . Italian Ketogenic Mediterranean Diet in Overweight and Obese Patients with Prediabetes or Type 2 Diabetes. Nutrients. 2022; 14(20). PMC: 9610411. DOI: 10.3390/nu14204361. View

Masi D, Spoltore M, Rossetti R, Watanabe M, Tozzi R, Caputi A . The Influence of Ketone Bodies on Circadian Processes Regarding Appetite, Sleep and Hormone Release: A Systematic Review of the Literature. Nutrients. 2022; 14(7). PMC: 9002750. DOI: 10.3390/nu14071410. View

Alsharairi N . The Therapeutic Role of Short-Chain Fatty Acids Mediated Very Low-Calorie Ketogenic Diet-Gut Microbiota Relationships in Paediatric Inflammatory Bowel Diseases. Nutrients. 2022; 14(19). PMC: 9572225. DOI: 10.3390/nu14194113. View

Puchalska P, Crawford P . Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. Cell Metab. 2017; 25(2):262-284. PMC: 5313038. DOI: 10.1016/j.cmet.2016.12.022. View

Watanabe M, Singhal G, Fisher F, Beck T, Morgan D, Socciarelli F . Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis. Endocrine. 2019; 67(1):95-108. PMC: 7948212. DOI: 10.1007/s12020-019-02124-3. View

Astrup A, Larsen T, Harper A . Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss?. Lancet. 2004; 364(9437):897-9. DOI: 10.1016/S0140-6736(04)16986-9. View

10.

Caprio M, Infante M, Moriconi E, Armani A, Fabbri A, Mantovani G . Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE). J Endocrinol Invest. 2019; 42(11):1365-1386. DOI: 10.1007/s40618-019-01061-2. View

11.

Rinaldi R, De Nucci S, Castellana F, Di Chito M, Giannuzzi V, Shahini E . The Effects of Eight Weeks' Very Low-Calorie Ketogenic Diet (VLCKD) on Liver Health in Subjects Affected by Overweight and Obesity. Nutrients. 2023; 15(4). PMC: 9962649. DOI: 10.3390/nu15040825. View

12.

Ilyas Z, Perna S, Alalwan T, Zahid M, Spadaccini D, Gasparri C . The Ketogenic Diet: Is It an Answer for Sarcopenic Obesity?. Nutrients. 2022; 14(3). PMC: 8838342. DOI: 10.3390/nu14030620. View

13.

Bolsterli B, Boltshauser E, Palmieri L, Spenger J, Brunner-Krainz M, Distelmaier F . Ketogenic Diet Treatment of Defects in the Mitochondrial Malate Aspartate Shuttle and Pyruvate Carrier. Nutrients. 2022; 14(17). PMC: 9460686. DOI: 10.3390/nu14173605. View

14.

Basciani S, Camajani E, Contini S, Persichetti A, Risi R, Bertoldi L . Very-Low-Calorie Ketogenic Diets With Whey, Vegetable, or Animal Protein in Patients With Obesity: A Randomized Pilot Study. J Clin Endocrinol Metab. 2020; 105(9). DOI: 10.1210/clinem/dgaa336. View

15.

Mohammadifard N, Haghighatdoost F, Rahimlou M, Rodrigues A, Gaskarei M, Okhovat P . The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular Disease and Cancer. Nutrients. 2022; 14(17). PMC: 9459811. DOI: 10.3390/nu14173499. View

16.

Barrea L, Caprio M, Watanabe M, Cammarata G, Feraco A, Muscogiuri G . Could very low-calorie ketogenic diets turn off low grade inflammation in obesity? Emerging evidence. Crit Rev Food Sci Nutr. 2022; 63(26):8320-8336. DOI: 10.1080/10408398.2022.2054935. View

17.

Watanabe M, Balena A, Masi D, Tozzi R, Risi R, Caputi A . Rapid Weight Loss, Central Obesity Improvement and Blood Glucose Reduction Are Associated with a Stronger Adaptive Immune Response Following COVID-19 mRNA Vaccine. Vaccines (Basel). 2022; 10(1). PMC: 8780354. DOI: 10.3390/vaccines10010079. View

18.

Sanchez E, Santos M, Nunez-Garcia M, Bueno M, Sajoux I, Yeramian A . Randomized Clinical Trial to Evaluate the Morphological Changes in the Adventitial Vasa Vasorum Density and Biological Markers of Endothelial Dysfunction in Subjects with Moderate Obesity Undergoing a Very Low-Calorie Ketogenic Diet. Nutrients. 2022; 14(1). PMC: 8746664. DOI: 10.3390/nu14010033. View

19.

Youm Y, Nguyen K, Grant R, Goldberg E, Bodogai M, Kim D . The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015; 21(3):263-9. PMC: 4352123. DOI: 10.1038/nm.3804. View

20.

Basolo A, Magno S, Santini F, Ceccarini G . Ketogenic Diet and Weight Loss: Is There an Effect on Energy Expenditure?. Nutrients. 2022; 14(9). PMC: 9105638. DOI: 10.3390/nu14091814. View