Interferons-Implications in the Immune Response to Respiratory Viruses

Overview

Journal Microorganisms

Specialty Microbiology

Date 2023 Sep 28

PMID 37764023

Authors

Harrison C Bergeron

Matthew R Hansen

Ralph A Tripp

Affiliations

Soon will be listed here.

Abstract

Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that induce or antagonize IFN responses depending on various factors. In this review, the role and function of type I, II, and III IFN responses to respiratory virus infections are considered. In addition, the role of the viral proteins in modifying anti-viral immunity is noted, as are the specific IFN responses that underly the correlates of immunity and protection from disease.

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