Evaluation of the Effects of Radiation Therapy on Muscle Contractibility and Skin Healing: An Experimental Study of the Cancer Treatment Implications

Overview

Journal Life (Basel)

Specialty Biology

Date 2023 Sep 28

PMID 37763242

Authors

Sarah O M Avelino

Rafael M Neves

Leonardo A Sobral-Silva

Rubens N Tango

Claudio A Federico

Mariana R C Vegian

Luis Augusto de Almeida-Silva

Estela Kaminagakura

Jose Benedito O Amorim

Luana M R Vasconcellos

Affiliations

Soon will be listed here.

Abstract

Background: Radiotherapy can affect healthy cells, resulting in side effects. This study aimed to assess the impact of radiotherapy on soft tissue in surgical wounds in rats.

Methods: The animals were divided into four groups: control (S) group without irradiation, immediate irradiation (S-IIr) group receiving irradiation right after surgery, late irradiation (S-LIr) group receiving irradiation four weeks after surgery, and early irradiation (Ir-S) group receiving irradiation before surgery. The irradiated groups underwent two fractional stages of 15 Gy. Muscle contractibility (EMG) was evaluated at two different time points, and after 2 and 7 weeks, the animals were euthanized for histological analysis of the muscles and skin.

Results: There was no significant difference between the EMG1 and EMG2 values of the S and S-LIr groups, but both S-IIr and Ir-S groups exhibited a statistically significant difference. The S group demonstrated a larger diameter of muscle fiber compared to other groups, showing a significant difference. In terms of skin analysis, the S-IIr group had the least inflammatory infiltrate and the highest amount of red fibers, differing significantly from the other groups.

Conclusions: Regardless of the duration, radiotherapy was found to have effects on the surrounding soft tissues, as concluded by this study.

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