Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Sep 28

PMID 37762647

Authors

Vadim E Tseilikman

Vladislav A Shatilov

Maxim S Zhukov

Irina A Buksha

Alexandr E Epitashvily

Ilya A Lipatov

Maxim R Aristov

Alexandr G Koshelev

Marina N Karpenko

Dmitrii S Traktirov

Viktoriya A Maistrenko

Mustapha Kamel

Alexey V Buhler

Elena G Kovaleva

Tatyana S Kalinina

Anton A Pashkov

Vadim V Konkov

Jurica Novak

Olga B Tseilikman

Affiliations

Soon will be listed here.

Abstract

Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing and Freezing phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD.

Citing Articles

Unraveling the Serotonergic Mechanism of Stress-Related Anxiety: Focus on Co-Treatment with Resveratrol and Selective Serotonin Reuptake Inhibitors.

Tseilikman V, Tseilikman O, Karpenko M, Traktirov D, Obukhova D, Shatilov V Biomedicines. 2024; 12(11).

PMID: 39595020 PMC: 11591826. DOI: 10.3390/biomedicines12112455.

Unraveling the Liver-Brain Axis: Resveratrol's Modulation of Key Enzymes in Stress-Related Anxiety.

Tseilikman V, Tseilikman O, Shevyrin V, Yegorov O, Epitashvili A, Aristov M Biomedicines. 2024; 12(9).

PMID: 39335576 PMC: 11428544. DOI: 10.3390/biomedicines12092063.

Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders-An Overview of Experimental Evidence.

Tseilikman V, Tseilikman O, Yegorov O, Brichagina A, Karpenko M, Tseilikman D Nutrients. 2024; 16(17).

PMID: 39275174 PMC: 11396965. DOI: 10.3390/nu16172856.

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