» Articles » PMID: 37762248

Pregnancy by Oocyte Donation: Reviewing Fetal-Maternal Risks and Complications

Overview
Journal Int J Mol Sci
Publisher MDPI
Date 2023 Sep 28
PMID 37762248
Authors
Affiliations
Soon will be listed here.
Abstract

Oocyte donation (OD) has greatly improved over the last three decades, becoming a preferred practice of assisted reproductive technology (ART) for infertile women wishing for motherhood. Through OD, indeed, it has become possible to overcome the physiological limitation due to the ovarian reserve (OR) exhaustion as well as the poor gamete reliability which parallels the increasing age of women. However, despite the great scientific contribution related to the success of OD in the field of infertility, this practice seems to be associated with a higher rate of major risky events during pregnancy as recurrent miscarriage, infections and placental diseases including gestational hypertension, pre-eclampsia and post-partum hemorrhage, as well as several maternal-fetal complications due to gametes manipulation and immune system interaction. Here, we will revisit this questioned topic since a number of studies in the medical literature focus on the successful aspects of the OD procedure in terms of pregnancy rate without, however, neglecting the risks and complications potentially linked to external manipulation or heterologous implantation.

Citing Articles

Live birth rate after oocyte donation in females diagnosed with turner syndrome: a systematic review and meta-analysis.

Rashidian P, Parsaei M, Karami S, Sharifi T, Sadin Z, Salehi S BMC Pregnancy Childbirth. 2024; 24(1):605.

PMID: 39294592 PMC: 11411911. DOI: 10.1186/s12884-024-06801-8.


Uterine Aging and Reproduction: Dealing with a Puzzle Biologic Topic.

Tinelli A, Andjic M, Morciano A, Pecorella G, Malvasi A, Damato A Int J Mol Sci. 2024; 25(1).

PMID: 38203493 PMC: 10778867. DOI: 10.3390/ijms25010322.

References
1.
Silvestris E, DOronzo S, Cafforio P, DAmato G, Loverro G . Perspective in infertility: the ovarian stem cells. J Ovarian Res. 2015; 8:55. PMC: 4528806. DOI: 10.1186/s13048-015-0184-9. View

2.
Kalra S, Ratcliffe S, Coutifaris C, Molinaro T, Barnhart K . Ovarian stimulation and low birth weight in newborns conceived through in vitro fertilization. Obstet Gynecol. 2011; 118(4):863-71. PMC: 3178887. DOI: 10.1097/AOG.0b013e31822be65f. View

3.
Menezo Y, Dale B, Cohen M . DNA damage and repair in human oocytes and embryos: a review. Zygote. 2010; 18(4):357-65. DOI: 10.1017/S0967199410000286. View

4.
Roberts J . Pathophysiology of ischemic placental disease. Semin Perinatol. 2014; 38(3):139-45. PMC: 4040272. DOI: 10.1053/j.semperi.2014.03.005. View

5.
Fauser B . Towards the global coverage of a unified registry of IVF outcomes. Reprod Biomed Online. 2018; 38(2):133-137. DOI: 10.1016/j.rbmo.2018.12.001. View