Antiviral Activity of Anthranilamide Peptidomimetics Against Herpes Simplex Virus 1 and a Coronavirus

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2023 Sep 28

PMID 37760732

Authors

Umme Laila Urmi

Samuel Attard

Ajay Kumar Vijay

Mark D P Willcox

Naresh Kumar

Salequl Islam

Rajesh Kuppusamy

Affiliations

Soon will be listed here.

Abstract

The development of potent antiviral agents is of utmost importance to combat the global burden of viral infections. Traditional antiviral drug development involves targeting specific viral proteins, which may lead to the emergence of resistant strains. To explore alternative strategies, we investigated the antiviral potential of antimicrobial peptidomimetic compounds. In this study, we evaluated the antiviral potential of 17 short anthranilamide-based peptidomimetic compounds against two viruses: Murine hepatitis virus 1 (MHV-1) which is a surrogate of human coronaviruses and herpes simplex virus 1 (HSV-1). The half-maximal inhibitory concentration (IC) values of these compounds were determined in vitro to assess their potency as antiviral agents. Compounds and displayed the most potent inhibitory effects with IC values of 2.38 μM, and 6.3 μM against MHV-1 while compounds and showed IC values of 14.8 μM and 13 μM against HSV-1. Multiple antiviral assessments and microscopic images obtained through transmission electron microscopy (TEM) collectively demonstrated that these compounds exert a direct influence on the viral envelope. Based on this outcome, it can be concluded that peptidomimetic compounds could offer a new approach for the development of potent antiviral agents.

Citing Articles

Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings.

Mishra S, Akter T, Urmi U, Enninful G, Sara M, Shen J Antibiotics (Basel). 2025; 14(1).

PMID: 39858343 PMC: 11762091. DOI: 10.3390/antibiotics14010057.

Exploring the Efficacy of Peptides and Mimics against Influenza A Virus, Adenovirus, and Murine Norovirus.

Urmi U, Vijay A, Willcox M, Attard S, Enninful G, Kumar N Int J Mol Sci. 2024; 25(13).

PMID: 39000138 PMC: 11240954. DOI: 10.3390/ijms25137030.

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