MicroRNAs Can Influence Ovarian Cancer Progression by Dysregulating Integrin Activity

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2023 Sep 28

PMID 37760437

Authors

Zacharias Fasoulakis

Michaela-Zoi Psarommati

Angeliki Papapanagiotou

Vasilios Pergialiotis

Antonios Koutras

Athanasios Douligeris

Anastasia Mortaki

Antonios Mihail

Marianna Theodora

Sofoklis Stavros

Defkalion Karakalpakis

Maria Papamihail

Emmanuel N Kontomanolis

George Daskalakis

Panos Antsaklis

Affiliations

Soon will be listed here.

Abstract

Ovarian cancer is a deadly disease that affects thousands of women worldwide. Integrins, transmembrane receptors that mediate cell adhesion and signaling, play important roles in ovarian cancer progression, metastasis, and drug resistance. Dysregulated expression of integrins is implicated in various cellular processes, such as cell migration, invasion, and proliferation. Emerging evidence suggests that microRNAs (miRNAs) can regulate integrin expression and function, thus affecting various physiological and pathological processes, including ovarian cancer. In this article, we review the current understanding of integrin-mediated cellular processes in ovarian cancer and the roles of miRNAs in regulating integrins. We also discuss the therapeutic potential of targeting miRNAs that regulate integrins for the treatment of ovarian cancer. Targeting miRNAs that regulate integrins or downstream signaling pathways of integrins may provide novel therapeutic strategies for inhibiting integrin-mediated ovarian cancer progression.

Citing Articles

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