Artificial Switches Induce the Bespoke Production of Functional Compounds in Marine Microalgae Chlorella by Neutralizing CO

Overview

Journal Biotechnol Biofuels Bioprod

Publisher Biomed Central

Date 2023 Sep 27

PMID 37759320

Authors

Jiahua Gu

Yuan Xiao

Mingcan Wu

Aoqi Wang

Xinyu Cui

Yi Xin

Kalyanee Paithoonrangsarid

Yandu Lu

Affiliations

Soon will be listed here.

Abstract

To improve the CO tolerance of a marine microalga Chlorella sp. of which the production capacity has been demonstrated industrially, a mutant library was created and a strain hct53 was screened. Compared to the parental strain, hct53 shows a high CO capture capacity, while starch biosynthesis is compromised, with increases in health beneficial metabolites and antioxidant capacity. Global gene expression and genome-wide mutation distribution revealed that transcript choreography was concomitant with more active CO sequestration, an increase in the lipid synthesis, and a decrease in the starch and protein synthesis. These results suggest that artificial trait improvement via mutagenesis, couple with multiomics analysis, helps discover genetic switches that induce the bespoke conversion of carbon flow from "redundant metabolites" to valuable ones for functional food.

Citing Articles

Correction: Artificial switches induce the bespoke production of functional compounds in marine microalgae Chlorella by neutralizing CO.

Gu J, Xiao Y, Wu M, Wang A, Cui X, Xin Y Biotechnol Biofuels Bioprod. 2023; 16(1):176.

PMID: 37974281 PMC: 10655297. DOI: 10.1186/s13068-023-02423-y.

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