Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the SeAFOod Polyp Prevention Trial

Overview

Journal Cancer Prev Res (Phila)

Specialty Oncology

Date 2023 Sep 27

PMID 37756582

Authors

John R Davies

Tracey Mell

Harriett Fuller

Mark Harland

Rasha N M Saleh

Amanda D Race

Colin J Rees

Louise C Brown

Paul M Loadman

Amy Downing

Anne Marie Minihane

Elizabeth A Williams

Mark A Hull

Affiliations

Soon will be listed here.

Abstract

Prevention Relevance: Single-nucleotide polymorphisms in genes controlling lipid mediator signaling may modify the colorectal polyp prevention activity of aspirin. Further investigation is required to determine whether testing for genetic variants can be used to target cancer chemoprevention by aspirin to those who will benefit most.

Citing Articles

Fatty acid desaturase insertion-deletion polymorphism rs66698963 predicts colorectal polyp prevention by the n-3 fatty acid eicosapentaenoic acid: a secondary analysis of the seAFOod polyp prevention trial.

Sun G, Li Y, Davies J, Block R, Kothapalli K, Brenna J Am J Clin Nutr. 2024; 120(2):360-368.

PMID: 38879016 PMC: 11347814. DOI: 10.1016/j.ajcnut.2024.06.004.

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